Rabbit Anti-TP73 Recombinant Antibody (VS3-CJ137)
CAT#: VS3-CJ137
This product is a rabbit antibody that recognizes TP73.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27314/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44516/if_selected.jpg
Normal Tissue
Figure 3 Skin 1
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_8_5.jpg
Normal Tissue
Figure 5 Skin
Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (MOLT-4, RH-30, SCLC-21H, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078900-TP73
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse TP73
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry.
Target
- Alternative Names
- P73; CILD47
- Gene ID
- 7161
- UniProt ID
- O15350
- Sequence Similarities
- Belongs to the p53 family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.
- Protein Refseq
- NP_001119712.1; NP_001119713.1; NP_001119714.1
- Function
- Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity).
It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TP73"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1619z | Mouse Anti-TP73 Recombinant Antibody (clone 25G9) | WB, ICC, IHC, IP | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1519CT | Recombinant Mouse anti-Human TP73 Monoclonal antibody (FS-26) | GSA, ICC, IF, IHC-P, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3648 | Rabbit Anti-TP73 Recombinant Antibody (clone DS3648AB) | IHC-Fr, WB, IP, ICC, IF, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1157-CN | Rabbit Anti-TP73 Recombinant Antibody (clone CBACN-420) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1476 | Recombinant Rabbit Anti-TP73 Antibody (clone R07-1J7) | WB, IP, ChIP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY3528 | Rabbit Anti-TP73 Recombinant Antibody (clone R09-1J5) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7450 | Anti-TP73 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7451 | Anti-Mouse TP73 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7452 | Anti-Rat TP73 Immunohistochemistry Kit | IHC |
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