Rabbit Anti-TP73 Recombinant Antibody (VS3-CJ137) (CAT#: VS3-CJ137)
This product is a rabbit antibody that recognizes TP73.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/27314/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/27314/if_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44516/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44516/if_selected.jpg
Figure 3 Skin 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1_val_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_8_5.jpg
Figure 5 Skin
(Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1.jpg
(Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1.jpg
Figure 6 RNA cell line category: Cell line enhanced (MOLT-4, RH-30, SCLC-21H, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078900-TP73
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078900-TP73
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse TP73
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry.
Target
- Alternative Names
- P73; CILD47
- Gene ID
- 7161
- UniProt ID
- O15350
- Sequence Similarities
- Belongs to the p53 family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.
- Protein Refseq
- NP_001119712.1; NP_001119713.1; NP_001119714.1
- Function
- Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity).
It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1619z | Mouse Anti-TP73 Recombinant Antibody (clone 25G9) | WB, ICC, IHC, IP | Mouse IgG |
| MOB-1519CT | Recombinant Mouse anti-Human TP73 Monoclonal antibody (FS-26) | GSA, ICC/IF, IHC-P, IP, WB | |
| VS3-FY1476 | Recombinant Rabbit Anti-TP73 Antibody (clone R07-1J7) | WB, IP, ChIP | Rabbit IgG |
| VS3-XY3528 | Rabbit Anti-TP73 Recombinant Antibody (clone R09-1J5) | WB, IHC-P, ICC, IF | Rabbit IgG |
| VS13-YC1179 | Rabbit Anti-TP73 Recombinant Antibody (VS13-YC1179) | IHC-P | Rabbit IgG |
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