This product is a recombinant Human antibody that can recognize ZIKV E. At pH6.5, antibody C10 locks all virus surface E proteins, and at pH5.0, it locks the E protein raft structure.
Figure 1 Binding characteristics of used mAbs. Characteristics of the mAbs used for dimer assembly.
Several mouse or human (M/H) derived mAbs were used for sRecE dimer assembly, indicating their DENV and ZIKV binding potential. Flavivirus cross reactive (F-CR), weakly, medium or strong (W/M/S) neutralizing, E-domain I, II, III (DI, DII, DIII), fusion loop (FL), quaternary epitope (Q).
Metz, S. W., Gallichotte, E. N., Brackbill, A., Premkumar, L., Miley, M. J., Baric, R., & de Silva, A. M. (2017). In vitro assembly and stabilization of dengue and Zika virus envelope protein homo-dimers. Scientific reports, 7(1), 4524.
Figure 2 Antibody mediated dimer assembly.
Indicated amounts of DENV and ZIKV sRecE were incubated with 500 ng of C10 mAb in solution. Protein/mAb complexes were loaded on Ni²⁺-coated plates and captured antibodies were detected.
Metz, S. W., Gallichotte, E. N., Brackbill, A., Premkumar, L., Miley, M. J., Baric, R., & de Silva, A. M. (2017). In vitro assembly and stabilization of dengue and Zika virus envelope protein homo-dimers. Scientific reports, 7(1), 4524.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
PFBC-264 | Recombinant Human Anti-ZIKV E Antibody Fab Fragment (C10) | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-264 | Recombinant Human Anti-ZIKV E Antibody scFv Fragment (C10) | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-1560CQ | Human Anti-ZIKV E Recombinant Antibody (clone A9E) | Neut, WB, ELISA | Human IgG1 |
FAMAB-1765CQ | Human Anti-ZIKV E Recombinant Antibody (clone SMZAb5) | Neut, FuncS, ELISA | Human IgG1 |
FAMAB-1766CQ | Human Anti-ZIKV E Recombinant Antibody (clone SMZAb1) | Neut, FuncS, ELISA | Human IgG1 |
FAMAB-1767CQ | Human Anti-ZIKV E Recombinant Antibody (clone SMZAb2) | Neut, FuncS, ELISA | Human IgG1 |
FAMAB-1790CQ | Human Anti-ZIKV E Recombinant Antibody (clone ZKA185) | Neut | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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