Anti-MUC16 (clone ch11D10)-mc-MMAF ADC

Name: Anti-MUC16 (clone ch11D10)-mc-MMAF ADC
SKU: ADC-217LZY
Rating: 5 (1 reviews)

CAT#: ADC-217LZY

This ADC product is composed of an anti-MUC16 antibody (clone ch11D10) conjugated via mc linker to MMAF (ch11D10-mc-MMAF). It has demonstrated a response in ovarian cance treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression

Normal Tissue Figure 1 Cervix

Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (A-431, HeLa)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16

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Specifications

Antibody Overview
Chimeric Anti-MUC16 IgG1,ch11D10

Clone
ch11D10

Antibody Isotype
IgG1

Linker
mc (maleimidocaproyl)

Linker Class/Description
Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

Drug
MMAF (monomethyl auristatin F)

Drug Class/Description
Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

Introduction
MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Alternative Names
MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

Gene ID
94025

UniProt ID
B3KY81

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Datasheet

Datasheet - ADC-217LZY.pdf

MSDS

MSDS - ADC-217LZY.pdf

COA

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