Anti-MUC16 (clone ch11D10)-mc-MMAF ADC (CAT#: ADC-217LZY)

• Antibody Overview
• Chimeric Anti-MUC16 IgG1,ch11D10

• Clone
• ch11D10

• Antibody Isotype
• IgG1

• Linker
• mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• MMAF (monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

• Alternative Names
• MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

• Gene ID
• 94025

• UniProt ID
• B3KY81

• ADC-218LZY
• Anti-MUC16 (clone ch11D10)-vc-MMAF ADC

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