Human Anti-ITGAM (clone MAN-1) scFv-Fc Chimera
CAT#: VS-0425-FY75
ITGAM (Integrin alpha-M) is involved in leukocyte adhesion. This scFv-Fc fusion protein targets ITGAM and has potential applications in treating inflammatory and autoimmune diseases by modulating leukocyte interactions.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_A_8_8.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_B_4_4.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HMC-1, NB-4, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169896-ITGAM
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ITGAM
- Species Reactivity
- Human
- Clone
- MAN-1
- Applications
- Inhibition, Flow Cytometry, Immunoprecipitation
- Related Disease
- Systemic Lupus Erythematosus 6; Shwartzman Phenomenon
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunoprecipitation: 10 μg/mL
Flow Cytometry: 10 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Alpha M
- Gene ID
- 3684
- UniProt ID
- P11215
- Long Name
- Integrin Subunit Alpha M
- Cellular Localization
- Cell membrane, Membrane raft
- Post Translation Modifications
- Glycosylation at Asn86, Asn240, Asn391, Asn469, Asn692, Asn696, Asn734, Asn801, Asn880, Asn900, Asn911, Asn940, Asn946, Asn978, Asn993, Asn1021, Asn1044, Asn1050, and Asn1075
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ITAM_HUMAN (1411)
Glycosylation from GlyGen 19 sites, 12 N-linked glycans (8 sites)
- Protein Refseq
- XP_006721108.1; XP_011544152.1
- Function
- Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens.
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component.
It probably recognizes the R-G-D peptide in C3b.
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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