Human Anti-MIF scFv-Fc Chimera (VS-0425-FY149)

Name: Human Anti-MIF scFv-Fc Chimera (VS-0425-FY149)
SKU: VS-0425-FY149
Rating: 5 (1 reviews)

CAT#: VS-0425-FY149

The anti-MIF scFv-FC is a recombinant antibody fragment designed to target macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine implicated in various diseases, including cancer and autoimmune disorders. This scFv is engineered as a fusion protein with an Fc region to increase its stability and therapeutic potential.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3868/if_selected.jpg

Normal Tissue Figure 2 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5284/13362_A_8_5.jpg

Normal Tissue Figure 3 Testis

Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5284/13362_A_5_6.jpg

Normal Tissue Figure 4 Prostate

Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5284/13362_A_1_5.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (HEK93)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000240972-MIF

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Specifications

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
Human MIF

Species Reactivity
Human

Applications
Flow Cytometry, ELISA

Related Disease
Rheumatoid Arthritis, Systemic Juvenile and Systemic-Onset Juvenile Idiopathic Arthritis

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
The optimal dilution concentration is determined by the experiment.

Target

Alternative Names
Macrophage Migration Inhibitory Factor; Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor); Glycosylation-Inhibiting Factor; Phenylpyruvate Tautomerase; L-Dopachrome Tautomerase; L-Dopachrome Isomerase

Gene ID
4282

UniProt ID
P14174

Long Name
Macrophage Migration Inhibitory Factor

Sequence Similarities
Belongs to the MIF family.

Cellular Localization
Secreted; Cytoplasm

Post Translation Modifications
Ubiquitination at Lys78
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

Protein Refseq
NP_002406.1

Function
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens.
The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0425-FY149.pdf

MSDS

MSDS - VS-0425-FY149.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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