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MIF
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEK93)
Interaction
Homotrimer (PubMed:8610159, PubMed:23776208). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (PubMed:11089976, PubMed:12681488, PubMed:12782713, PubMed:19454686, PubMed:23776208).
Molecular function
Cytokine, Isomerase
More Types Infomation
- Recombinant Mouse Anti-MIF Antibody (10C3) (NEUT-1741CQ)
-
- Species Reactivity: Human
- Type: IgG2b, κ
- Application: ELISA(Cap), WB, Neut
- Mouse Anti-MIF Recombinant Antibody (clone 19G7) (MOB-1484z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF, IP, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP, FC
- Human Anti-MIF Recombinant Antibody; Fab Fragment (HPAB-0104-YC-F(E)) (HPAB-0104-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Activ
- Anti-Human MIF Recombinant Antibody (TAB-528CL)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Human Anti-MIF Recombinant Antibody; scFv Fragment (HPAB-0104-YC-S(P)) (HPAB-0104-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Activ
- Human Anti-MIF Recombinant Antibody (HPAB-0104-YC) (HPAB-0104-YC)
-
- Species Reactivity: Human
- Type: Human IgG4
- Application: ELISA, Activ
- Mouse Anti-MIF Recombinant Antibody; Fab Fragment (TAB-0811CL-F(E)) (TAB-0811CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; Fab Fragment (TAB-0810CL-F(E)) (TAB-0810CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; scFv Fragment (TAB-0811CL-S(P)) (TAB-0811CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; scFv Fragment (TAB-0810CL-S(P)) (TAB-0810CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; scFv Fragment (TAB-0809CL-S(P)) (TAB-0809CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; Fab Fragment (TAB-0809CL-F(E)) (TAB-0809CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; Fab Fragment (TAB-0808CL-F(E)) (TAB-0808CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; Fab Fragment (TAB-0807CL-F(E)) (TAB-0807CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; Fab Fragment (TAB-0806CL-F(E)) (TAB-0806CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; scFv Fragment (TAB-0808CL-S(P)) (TAB-0808CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-MIF Recombinant Antibody; scFv Fragment (TAB-0807CL-S(P)) (TAB-0807CL-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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