Human Anti-ROR2 scFv-Fc Chimera (VS-0325-FY35) (CAT#: VS-0325-FY35)
The anti-ROR2 scFv-Fc antibody is designed to specifically target the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2), a protein involved in developmental processes and cancer progression. It is engineered as a single-chain variable fragment (scFv)fused to an Fc region, enhancing its stability and half-life for therapeutic applications. This antibody has potential applications in cancer immunotherapy, particularly for tumors that overexpress ROR2, such as ovarian and colorectal cancer.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows distinct cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows distinct cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_B_8_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_B_8_5.jpg
Figure 3 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_9_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_9_3.jpg
Figure 4 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_7_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_7_4.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_8_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_8_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_4_6.jpg
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_4_6.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_9_8.jpg
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (AF22, HHSteC, HSkMC, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169071-ROR2/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169071-ROR2/subcellular
Specifications
- Immunogen
- The entirely extracellular domain of C-terminally tagged with a Twin-Strep-tag (hROR2-TwinStrep).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ROR2
- Species Reactivity
- Human, Cynomolgus
- Applications
- ELISA
- Related Disease
- Colorectal cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Receptor Tyrosine Kinase Like Orphan Receptor 2; NTRKR2; Tyrosine-Protein Kinase Transmembrane Receptor ROR2; Neurotrophic Tyrosine Kinase, Receptor-Related 2; Receptor Tyrosine Kinase-Like Orphan Receptor 2; Neurotrophic Tyrosine Kinase Receptor-Related 2; EC 2.7.10.1; BDB1; BDB
- Gene ID
- 4920
- UniProt ID
- Q01974
- Long Name
- Receptor Tyrosine Kinase Like Orphan Receptor 2
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn70, Thr157, Asn188, and Asn318
Ubiquitination at Lys489
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_005252065.1; XP_005252066.1; XP_006717184.1; XP_016870251.1; XP_047279390.1
- Function
- ROR2 (Receptor tyrosine kinase-like Orphan Receptor 2) is a cell surface receptor crucial in skeletal and craniofacial development. It's involved in Wnt signaling pathways, influencing cell proliferation, differentiation, and migration. Dysregulation of ROR2 is linked to various developmental disorders, highlighting its role in proper tissue formation.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| HPAB-M0202-YC-F(E) | Rabbit Anti-ROR2 Recombinant Antibody; Fab Fragment (HPAB-M0202-YC-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-M0203-YC-F(E) | Rabbit Anti-ROR2 Recombinant Antibody; Fab Fragment (HPAB-M0203-YC-F(E)) | ELISA, FC | Rabbit Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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