Human Anti-ROR2 scFv-Fc Chimera (VS-0325-FY35)
CAT#: VS-0325-FY35
The anti-ROR2 scFv-Fc antibody is designed to specifically target the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2), a protein involved in developmental processes and cancer progression. It is engineered as a single-chain variable fragment (scFv)fused to an Fc region, enhancing its stability and half-life for therapeutic applications. This antibody has potential applications in cancer immunotherapy, particularly for tumors that overexpress ROR2, such as ovarian and colorectal cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21868/50700_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AF22, HHSteC, HSkMC, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169071-ROR2/subcellular
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ROR2
- Species Reactivity
- Human, Cynomolgus
- Applications
- ELISA
- Related Disease
- Colorectal cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Receptor Tyrosine Kinase Like Orphan Receptor 2; NTRKR2; Tyrosine-Protein Kinase Transmembrane Receptor ROR2; Neurotrophic Tyrosine Kinase, Receptor-Related 2; Receptor Tyrosine Kinase-Like Orphan Receptor 2; Neurotrophic Tyrosine Kinase Receptor-Related 2; EC 2.7.10.1; BDB1; BDB
- Gene ID
- 4920
- UniProt ID
- Q01974
- Long Name
- Receptor Tyrosine Kinase Like Orphan Receptor 2
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn70, Thr157, Asn188, and Asn318
Ubiquitination at Lys489
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_005252065.1; XP_005252066.1; XP_006717184.1; XP_016870251.1; XP_047279390.1
- Function
- ROR2 (Receptor tyrosine kinase-like Orphan Receptor 2) is a cell surface receptor crucial in skeletal and craniofacial development. It's involved in Wnt signaling pathways, influencing cell proliferation, differentiation, and migration. Dysregulation of ROR2 is linked to various developmental disorders, highlighting its role in proper tissue formation.
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| HPAB-M0201-YC-F(E) | Rabbit Anti-ROR2 Recombinant Antibody; Fab Fragment (HPAB-M0201-YC-F(E)) | ELISA, FC | Rabbit Fab |
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