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ROR2

AbPlus Recombinant Antibody Products Formats Research Area

Anti-ROR2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Endometrial stromal cells, Inhibitory neurons, Endometrial ciliated cells, Microglial cells, Fibroblasts)

Immune cell specificity

Immune cell enriched (MAIT T-cell)

Cell line specificity

Cell line enhanced (AF22, HHSteC, HSkMC, U-266/70, U-266/84)

Interaction

Homodimer; promotes osteogenesis. Binds YWHAB (PubMed:17717073). Interacts with WTIP (By similarity).

Molecular function

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

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Related Signaling Pathways
Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway Non-Canonical Wnt Signaling Pathway
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