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    ROR2

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
    Protein class

    Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Oligodendrocyte precursor cells, Endometrial stromal cells, Inhibitory neurons, Endometrial ciliated cells, Microglial cells, Fibroblasts)

    Immune cell specificity

    Immune cell enriched (MAIT T-cell)

    Cell line specificity

    Cell line enhanced (AF22, HHSteC, HSkMC, U-266/70, U-266/84)

    Interaction

    Homodimer; promotes osteogenesis. Binds YWHAB (PubMed:17717073). Interacts with WTIP (By similarity).

    Molecular function

    Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

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    Related Signaling Pathways
    Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
    Non-Canonical Wnt Signaling Pathway Non-Canonical Wnt Signaling Pathway
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