Human Anti-vWF (clone AJvW-2) scFv-Fc Chimera
CAT#: VS-0125-FY41
The scFv-Fc antibodies targeting vWF were designed with a specificity strategy aimed at precisely recognizing and binding to vWF, thereby promoting a deeper understanding of its structure and function. By applying these antibodies, researchers can conduct detailed epitope mapping analysis to reveal the interactions and binding affinities between vWF and other factors, such as FVIII. This will not only advance fundamental scientific research but may also provide new ideas and applications for therapeutic strategies targeting blood disorders in clinical settings.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_A_9_3.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110799-VWF
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- AJvW-2
- Applications
- ELISA, Blocking
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- These scFvs, by binding to vWF, may be used to study the interaction between vWF and FVIII, particularly in analyzing the functionality and role of the vWF/FVIII complex in plasma samples. Additionally, these antibodies may also be used in clinical or research settings to detect vWF-related diseases.
Target
- Alternative Names
- Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF
- Gene ID
- 7450
- Cellular Localization
- Extracellular matrix, Secreted
- Post Translation Modifications
- All cysteine residues are involved in intrachain or interchain disulfide bonds.
N- and O-glycosylated.
Glycosylation at Asn99, Asn156, Asn211, Asn368, Asn666, Asn857, Asn1147, Asn1231, Thr1248, Thr1255, Thr1256, Ser1263, Thr1468, Thr1477, Ser1486, Thr1487, Asn1515, Asn1574, Thr1679, Asn2223, Asn2290, Thr2298, Asn2357, Asn2400, Asn2546, Asn2585, and Asn2790
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect VWF_HUMAN (627)
Glycosylation from GlyGen 30 sites, 112 N-linked glycans (12 sites), 10 O-linked glycans (8 sites)
- Protein Refseq
- XP_047285457.1; XP_054229108.1; NP_000543.3
- Function
- Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone AJvW-2"
- CAT
- Product Name
See other products for "VWF"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-132 | Mouse Anti-VWF Recombinant Antibody (clone 82D6A3) | WB, IF, FuncS | Mouse IgG |
| PABW-132 | Mouse Anti-VWF Recombinant Antibody (clone NMC-4) | Block, Inhib, WB, DB | Mouse IgG |
| PABC-133 | Mouse Anti-vWF Recombinant Antibody (clone RU5) | ELISA, WB, IHC, IF, Inhib, FuncS | Mouse IgG |
| MOB-177CQ | Mouse Anti-VWF Recombinant Antibody (clone YC161) | WB, IP, IF, IHC-P | Mouse IgG1, κ |
| HPAB-M0250-YC | Mouse Anti-VWF Recombinant Antibody (clone SZ123) | Inhib, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-132 | Mouse Anti-VWF Recombinant Antibody (clone 82D6A3); Fab Fragment | WB, IF, FuncS | Mouse Fab |
| PFBW-132 | Mouse Anti-VWF Recombinant Antibody (clone NMC-4); Fab Fragment | Block | Mouse Fab |
| PFBC-133 | Mouse Anti-VWF Recombinant Antibody (clone RU5); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| HPAB-0343-WJ-F(E) | Mouse Anti-VWF Recombinant Antibody; Fab Fragment (HPAB-0343-WJ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-M0250-YC-F(E) | Mouse Anti-VWF Recombinant Antibody (clone SZ123); Fab Fragment | Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-132 | Mouse Anti-VWF Recombinant Antibody (clone 82D6A3); scFv Fragment | WB, IF, FuncS | Mouse scFv |
| PSBW-132 | Mouse Anti-VWF Recombinant Antibody (clone NMC-4); scFv Fragment | Block | Mouse scFv |
| PSBC-133 | Mouse Anti-VWF Recombinant Antibody (clone RU5); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| FAMAB-0297-YC-S(P) | Human Anti-VWF Recombinant Antibody (clone h82D6A3); scFv Fragment | ELISA, WB | Humanized scFv |
| FAMAB-0298-YC-S(P) | Mouse Anti-VWF Recombinant Antibody (clone m-82D6A3); scFv Fragment | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-362CQ | Anti-Human VWF Recombinant Antibody (AJvW-2) | ELISA, BL | |
| TAB-362CQ-S(P) | Anti-Human VWF Recombinant Antibody scFv Fragment (AJvW-2) | ELISA, BL | |
| TAB-363CQ-S(P) | Mouse Anti-VWF Recombinant Antibody; scFv Fragment (TAB-363CQ-S(P)) | ELISA, WB, Inhib | Mouse scFv |
| TAB-362CQ-F(E) | Anti-Human VWF Recombinant Antibody Fab Fragment (AJvW-2) | ELISA, BL | |
| TAB-363CQ-F(E) | Mouse Anti-VWF Recombinant Antibody; Fab Fragment (TAB-363CQ-F(E)) | ELISA, WB, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-364CQ | Human Anti-VWF Recombinant Antibody (TAB-364CQ) | Inhib | Humanized antibody |
| TAB-364CQ-S(P) | Human Anti-VWF Recombinant Antibody; scFv Fragment (TAB-364CQ-S(P)) | Inhib | Humanized scFv |
| TAB-364CQ-F(E) | Human Anti-VWF Recombinant Antibody; Fab Fragment (TAB-364CQ-F(E)) | Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-365CQ | Human Anti-VWF Recombinant Antibody (TAB-365CQ) | Inhib | Chimeric antibody (mouse/human) |
| TAB-365CQ-S(P) | Mouse Anti-VWF Recombinant Antibody; scFv Fragment (TAB-365CQ-S(P)) | Inhib | Mouse scFv |
| TAB-365CQ-F(E) | Human Anti-VWF Recombinant Antibody; Fab Fragment (TAB-365CQ-F(E)) | Inhib | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3860 | Rabbit Anti-VWF Recombinant Antibody (clone DS3860AB) | WB, ICC, IF | Rabbit IgG |
| MOR-0109-FY | Rabbit Anti-VWF Recombinant Antibody (clone AFY0080) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1628-FY | Llama Anti-VWF Recombinant Single Domain Antibody (HPAB-1628-FY) | ELISA | Llama VHH |
| HPAB-1629-FY | Llama Anti-VWF Recombinant Single Domain Antibody (HPAB-1629-FY) | ELISA | Llama VHH |
| HPAB-1630-FY | Llama Anti-VWF Recombinant Single Domain Antibody (HPAB-1630-FY) | Inhib, ELISA | Llama VHH |
| HPAB-1631-FY | Recombinant Llama Anti-VWF Single Domain Antibody (HPAB-1631-FY) | ELISA, SPR, FC | Llama VHH |
| HPAB-1632-FY | Recombinant Llama Anti-VWF Single Domain Antibody (HPAB-1632-FY) | Inhib | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2481 | Anti-VWF Immunohistochemistry Kit | IHC | |
| VS-0525-XY7888 | Anti-Mouse VWF Immunohistochemistry Kit | IHC | |
| VS-0525-XY7887 | Anti-Human VWF Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC327 | Recombinant Anti-VWF Eliminating Antibody, pH-Sensitive (F8/86 var.) | Antigen-Sweeping In Vivo. | Human IgG1 |
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