Human Anti-vWF (clone AJvW-2) scFv-Fc Chimera (CAT#: VS-0125-FY41)
The scFv-Fc antibodies targeting vWF were designed with a specificity strategy aimed at precisely recognizing and binding to vWF, thereby promoting a deeper understanding of its structure and function. By applying these antibodies, researchers can conduct detailed epitope mapping analysis to reveal the interactions and binding affinities between vWF and other factors, such as FVIII. This will not only advance fundamental scientific research but may also provide new ideas and applications for therapeutic strategies targeting blood disorders in clinical settings.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_B_8_5.jpg
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_B_8_5.jpg
Figure 2 Colon
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_A_9_3.jpg
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1694/4967_A_9_3.jpg
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000110799-VWF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000110799-VWF
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110799-VWF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110799-VWF
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- AJvW-2
- Applications
- ELISA, Blocking
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- These scFvs, by binding to vWF, may be used to study the interaction between vWF and FVIII, particularly in analyzing the functionality and role of the vWF/FVIII complex in plasma samples. Additionally, these antibodies may also be used in clinical or research settings to detect vWF-related diseases.
Target
- Alternative Names
- Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF
- Gene ID
- 7450
- Cellular Localization
- Extracellular matrix, Secreted
- Post Translation Modifications
- All cysteine residues are involved in intrachain or interchain disulfide bonds.
N- and O-glycosylated.
Glycosylation at Asn99, Asn156, Asn211, Asn368, Asn666, Asn857, Asn1147, Asn1231, Thr1248, Thr1255, Thr1256, Ser1263, Thr1468, Thr1477, Ser1486, Thr1487, Asn1515, Asn1574, Thr1679, Asn2223, Asn2290, Thr2298, Asn2357, Asn2400, Asn2546, Asn2585, and Asn2790
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect VWF_HUMAN (627)
Glycosylation from GlyGen 30 sites, 112 N-linked glycans (12 sites), 10 O-linked glycans (8 sites)
- Protein Refseq
- XP_047285457.1; XP_054229108.1; NP_000543.3
- Function
- Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-132 | Mouse Anti-VWF Recombinant Antibody (clone 82D6A3); Fab Fragment | WB, IF, FuncS | Mouse Fab |
| PFBW-132 | Mouse Anti-VWF Recombinant Antibody (clone NMC-4); Fab Fragment | Block | Mouse Fab |
| FAMAB-0297-YC-F(E) | Human Anti-VWF Recombinant Antibody (clone h82D6A3); Fab Fragment | ELISA, WB | Humanized Fab |
| FAMAB-0298-YC-F(E) | Mouse Anti-VWF Recombinant Antibody (clone m-82D6A3); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0343-WJ-F(E) | Mouse Anti-VWF Recombinant Antibody; Fab Fragment (HPAB-0343-WJ-F(E)) | ELISA, WB | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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