Human Anti-vWF (clone AJvW-2) scFv-Fc Chimera (CAT#: VS-0125-FY41)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• AJvW-2

• Applications
• ELISA, Blocking

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• These scFvs, by binding to vWF, may be used to study the interaction between vWF and FVIII, particularly in analyzing the functionality and role of the vWF/FVIII complex in plasma samples. Additionally, these antibodies may also be used in clinical or research settings to detect vWF-related diseases.

• Alternative Names
• Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF

• Gene ID
• 7450

• Cellular Localization
• Extracellular matrix, Secreted

• Post Translation Modifications
• All cysteine residues are involved in intrachain or interchain disulfide bonds.
  N- and O-glycosylated.
  Glycosylation at Asn99, Asn156, Asn211, Asn368, Asn666, Asn857, Asn1147, Asn1231, Thr1248, Thr1255, Thr1256, Ser1263, Thr1468, Thr1477, Ser1486, Thr1487, Asn1515, Asn1574, Thr1679, Asn2223, Asn2290, Thr2298, Asn2357, Asn2400, Asn2546, Asn2585, and Asn2790
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect VWF_HUMAN (627)
  Glycosylation from GlyGen 30 sites, 112 N-linked glycans (12 sites), 10 O-linked glycans (8 sites)

• Protein Refseq
• XP_047285457.1; XP_054229108.1; NP_000543.3

• Function
• Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• TAB-362CQ
• Anti-Human VWF Recombinant Antibody (AJvW-2)

• TAB-362CQ-S(P)
• Anti-Human VWF Recombinant Antibody scFv Fragment (AJvW-2)

• TAB-362CQ-F(E)
• Anti-Human VWF Recombinant Antibody Fab Fragment (AJvW-2)

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