anti-MIgG(Fc)-C-MD10 ADC (CAT#: ADC-1022-SMz)
This ADC product is composed of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MD10 (anti-mouse IgG(Fc)-CL-MD10). The antibody portion is a secondary antibody and the drug portion, monomethyl dolastatin 10 (MD10), is a cytotoxic small molecule which blocks the polymerization of tubulin. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening mouse monoclonal antibodies as ADC candidates.
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Specifications
- Antibody Overview
- anti-mouse IgG Fc specific polyclonal IgG antibody
- Antibody Isotype
- IgG
- Linker
- CL
- Linker Class/Description
- Class: Cleavable linkers
Description: Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell.
- Drug
- MD10 (monomethyl dolastatin 10 )
- Drug Class/Description
- Class: Dolastatin 10
Description: Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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scFv Fragment Antibody
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| MOB-548-S(P) | Recombinant Anti-IgG Fc Antibody scFv Fragment | WB, IF, FuncS | scFv |
| MHH-548-S(P) | Recombinant Human Anti-IgG Fc Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
| PSBZ-080 | Human Anti-IgG Fc Recombinant Antibody; scFv Fragment (PSBZ-080) | WB, IF, FuncS | Human scFv |
| HPAB-S0071-YC-S(P) | Human Anti-IgG Fc Recombinant Antibody (clone RF-AN); scFv Fragment | ELISA | Human scFv |
| FAMAB-0024JF-S(P) | Human Anti-IgG Fc Recombinant Antibody (clone NA6); scFv Fragment | WB, FC, ELISA, FuncS | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-548 | Recombinant Human Anti-IgG Fc Antibody | IF, Neut, FuncS | IgG |
| PABZ-080 | Human Anti-IgG Fc Recombinant Antibody (PABZ-080) | WB, IF, FuncS | Human IgG |
| HPAB-S0071-YC | Human Anti-IgG Fc Recombinant Antibody (clone RF-AN) | ELISA | Human IgM |
| FAMAB-0023JF | Human Anti-IgG Fc Recombinant Antibody (clone A4) | ELISA, FuncS | Human IgM |
| FAMAB-0024JF | Human Anti-IgG Fc Recombinant Antibody (clone NA6) | ELISA, FuncS | Human IgM |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-548-F(E) | Recombinant Human Anti-IgG Fc Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| PFBZ-080 | Human Anti-IgG Fc Recombinant Antibody; Fab Fragment (PFBZ-080) | WB, IF, FuncS | Human Fab |
| HPAB-S0071-YC-F(E) | Human Anti-IgG Fc Recombinant Antibody (clone RF-AN); Fab Fragment | ELISA | Human Fab |
| FAMAB-0023JF-F(E) | Human Anti-IgG Fc Recombinant Antibody (clone A4); Fab Fragment | WB, FC, ELISA, FuncS | Human Fab |
| FAMAB-0024JF-F(E) | Human Anti-IgG Fc Recombinant Antibody (clone NA6); Fab Fragment | WB, FC, ELISA, FuncS | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0356MC | FITC anti-Human IgG Fc Antibody | FC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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