Mouse Anti-HSP90AB1 scFv-Fc Chimera (VS-0325-FY190)
CAT#: VS-0325-FY190
This antibody is a recombinant single-chain variable fragment (scFv) derived from the H90-10 hybridoma, fused to the Fc region of mouse IgG2a. It specifically targets human Hsp90b, a molecular chaperone involved in various cellular processes. This antibody has been validated for use in immunoprecipitation and western blotting applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55729/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55729/958_C6_2_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55729/911_A5_1_blue_red_green.jpg
Normal Tissue
Figure 4 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/ihc_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Goblet cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_A_8_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining:MediumIntensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_A_7_5.jpg
Normal Tissue
Figure 9 Testis
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_A_6_6.jpg
Normal Tissue
Figure 10 Placenta
Decidual cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_A_2_7.jpg
Normal Tissue
Figure 11 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5230/15840_A_8_8.jpg
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000096384-HSP90AB1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2a, scFv-Fc
- Specificity
- Human HSP90AB1
- Species Reactivity
- Human
- Applications
- Western Blot, Immunoprecipitation
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Heat Shock Protein 90 Alpha Family Class B Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1; Heat Shock 90kD Protein 1, Beta; Heat Shock 84 KDa; HSP90B; HSPC2; HSPCB; HSP84; Heat Shock Protein 90kDa Alpha Family Class B Member 1
- Gene ID
- 3326
- UniProt ID
- P08238
- Long Name
- Heat Shock Protein 90 Alpha Family Class B Member 1
- Sequence Similarities
- Belongs to the heat shock protein 90 family.
- Cellular Localization
- Cytoplasm; Melanosome; Nucleus; Secreted; Cell membrane; Dynein axonemal particle; Cell surface
- Post Translation Modifications
- Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity.
Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide.
Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.
Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
Glycosylation at Asn46, Asn389, Ser434, and Ser452
Ubiquitination at Lys306, Lys411, Lys428, Lys435, Lys438, Lys481, Lys491, Lys505, and Lys624
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect HS90B_HUMAN (1302)
Glycosylation from GlyGen 6 sites, 4 N-linked glycans (3 sites), 2 O-linked glycans (1 site)
- Protein Refseq
- NP_001258898.1; NP_001258899.1; NP_001258900.1; NP_001258901.1; NP_001358167.1
- Function
- Human HSP90AB1 (Heat shock protein 90 alpha family class B member 1) is a molecular chaperone involved in protein folding, stability, and signal transduction. It plays a critical role in cellular stress responses and is implicated in cancer and other diseases.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-516 | Recombinant Anti-human HSP90AB1 Antibody | WB, ELISA, IHC, FuncS | IgG |
| MRO-0782-CN | Rabbit Anti-HSP90AB1 Recombinant Antibody (clone CBACN-293) | WB, IF, IHC, IP, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
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| MOB-516-F(E) | Recombinant Anti-human HSP90AB1 Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| MHH-516-F(E) | Recombinant Human Anti-human HSP90AB1 Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
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| MOB-516-S(P) | Recombinant Anti-human HSP90AB1 Antibody scFv Fragment | WB, IHC, FuncS | scFv |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MHC-LC3385 | PE-A2/Human HSP90AB1 (ILDKKVEKV) MHC Tetramer | FCM | |
| MHC-LC3387 | PE-B*27:05/Human HSP90AB1 (RRVKEVVKK) MHC Tetramer | FCM | |
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| CAT | Product Name | Application | Type |
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