Mouse Anti-HSP90AB1 scFv-Fc Chimera (VS-0325-FY190) (CAT#: VS-0325-FY190)

• Host Species
• Mouse

• Type
• Mouse IgG2a, scFv-Fc

• Specificity
• Human HSP90AB1

• Species Reactivity
• Human

• Applications
• Western Blot, Immunoprecipitation

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Heat Shock Protein 90 Alpha Family Class B Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1; Heat Shock 90kD Protein 1, Beta; Heat Shock 84 KDa; HSP90B; HSPC2; HSPCB; HSP84; Heat Shock Protein 90kDa Alpha Family Class B Member 1

• Gene ID
• 3326

• UniProt ID
• P08238

• Long Name
• Heat Shock Protein 90 Alpha Family Class B Member 1

• Sequence Similarities
• Belongs to the heat shock protein 90 family.

• Cellular Localization
• Cytoplasm; Melanosome; Nucleus; Secreted; Cell membrane; Dynein axonemal particle; Cell surface

• Post Translation Modifications
• Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
  ISGylated.
  S-nitrosylated; negatively regulates the ATPase activity.
  Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide.
  Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.
  Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
  Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
  Glycosylation at Asn46, Asn389, Ser434, and Ser452
  Ubiquitination at Lys306, Lys411, Lys428, Lys435, Lys438, Lys481, Lys491, Lys505, and Lys624
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect HS90B_HUMAN (1302)
  Glycosylation from GlyGen 6 sites, 4 N-linked glycans (3 sites), 2 O-linked glycans (1 site)

• Protein Refseq
• NP_001258898.1; NP_001258899.1; NP_001258900.1; NP_001258901.1; NP_001358167.1

• Function
• Human HSP90AB1 (Heat shock protein 90 alpha family class B member 1) is a molecular chaperone involved in protein folding, stability, and signal transduction. It plays a critical role in cellular stress responses and is implicated in cancer and other diseases.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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