Mouse Anti-LRRC15 scFv-Fc Chimera (VS-0425-FY145)
CAT#: VS-0425-FY145
Anti-LRRC15 scFv-FC targets leucine-rich repeat containing protein 15 (LRRC15), a protein expressed in various tumors and associated with tumor progression. This scFv-FC format enhances targeting for therapeutic applications, particularly in oncology, by facilitating immune recognition and promoting anti-tumor immune responses. It aims to leverage the specificity of the scFv combined with the enhanced properties provided by the Fc region.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/412_C1_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/89507_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/89507_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/89507_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/89507_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/89507_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35503/89507_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (fHDF/TERT166, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172061-LRRC15
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human LRRC15
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- LRRC15; LIB; Leucine rich repeat containing 15
- Gene ID
- 246296
- UniProt ID
- Q8R5M3
- Long Name
- Leucine rich repeat containing 15
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn75 and Asn369
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect LRC15_HUMAN (1451)
Glycosylation from GlyGen 2 sites, 3 N-linked glycans (1 site)
- Protein Refseq
- NP_001128529.2; NP_570843.2
- Function
- Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein.
Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-634 | Recombinant Human Anti-human LRRC15 Antibody | WB, IF, FuncS | IgG |
| HPAB-0230-WJ | Human Anti-LRRC15 Recombinant Antibody (HPAB-0230-WJ) | ELISA, FC | Humanized IgG1 |
| HPAB-0231-WJ | Human Anti-LRRC15 Recombinant Antibody (HPAB-0231-WJ) | ELISA, FC | Humanized IgG1 |
| HPAB-0232-WJ | Human Anti-LRRC15 Recombinant Antibody (HPAB-0232-WJ) | ELISA, FC | Humanized IgG1 |
| HPAB-0233-WJ | Human Anti-LRRC15 Recombinant Antibody (HPAB-0233-WJ) | ELISA, FC | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0709CL | Anti-Human LRRC15 Recombinant Antibody | ELISA | |
| TAB-0709CL-S(P) | Anti-Human LRRC15 Recombinant Antibody scFv Fragment | ELISA | |
| TAB-0709CL-F(E) | Anti-Human LRRC15 Recombinant Antibody Fab Fragment | ELISA | |
| MOB-0318MC | Rabbit Anti-Human ALRRC15 polyclonal Antibody | WB, IHC-P, IF, IHC-P |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2090 | Hi-Affi™ Recombinant Rabbit Anti-LRRC15 Monoclonal Antibody (DS2090AB) | WB, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0230-WJ-S(P) | Human Anti-LRRC15 Recombinant Antibody; scFv Fragment (HPAB-0230-WJ-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0231-WJ-S(P) | Human Anti-LRRC15 Recombinant Antibody; scFv Fragment (HPAB-0231-WJ-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0232-WJ-S(P) | Human Anti-LRRC15 Recombinant Antibody; scFv Fragment (HPAB-0232-WJ-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0233-WJ-S(P) | Human Anti-LRRC15 Recombinant Antibody; scFv Fragment (HPAB-0233-WJ-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0234-WJ-S(P) | Human Anti-LRRC15 Recombinant Antibody; scFv Fragment (HPAB-0234-WJ-S(P)) | ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0230-WJ-F(E) | Human Anti-LRRC15 Recombinant Antibody; Fab Fragment (HPAB-0230-WJ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0231-WJ-F(E) | Human Anti-LRRC15 Recombinant Antibody; Fab Fragment (HPAB-0231-WJ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0232-WJ-F(E) | Human Anti-LRRC15 Recombinant Antibody; Fab Fragment (HPAB-0232-WJ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0233-WJ-F(E) | Human Anti-LRRC15 Recombinant Antibody; Fab Fragment (HPAB-0233-WJ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0234-WJ-F(E) | Human Anti-LRRC15 Recombinant Antibody; Fab Fragment (HPAB-0234-WJ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC307 | Recombinant Anti-LRRC15 Vesicular Antibody, EV Displayed (VS-0425-YC307) | ELISA, FC, Cell-uptake |
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