Recombinant Anti-ADAM10 Vesicular Antibody, EV Displayed (VS-0425-YC400)
CAT#: VS-0425-YC400
The Recombinant Anti-ADAM10 Vesicular Antibody, EV Displayed (VS-0425-YC400) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ADAM10-expressed cells or tissues. The ADAM10 is a member of the ADAM family, functioning in protein cleavage and implicated in TNF-alpha processing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/50670/757_F11_4_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/211_C7_2_selected.jpg
Normal Tissue
Figure 3 IHC staining of human stomach
Immunohistochemical staining of human stomach shows moderate cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1709/4396_A_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137845-ADAM10
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ADAM10
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ADAM metallopeptidase domain 10
- Biological Process
- Notch signaling pathway
- Molecular Function
- Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Vesicles, Plasma membrane
- Introduction
- Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes an ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
- Alternative Names
- CD156C, HsT18717, kuz, MADM
- Gene ID
- 102
- UniProt ID
- O14672
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Datasheet
MSDS
COA
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See other products for "ADAM10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B003(A) | Recombinant Anti-human ADAM10 Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B003(G) | Recombinant Anti-human ADAM10 Intrabody [+36 GFP] | FACS, ELISA, IF, FuncS | scFv-(+36GFP) |
| IAB-B003(T) | Recombinant Anti-human ADAM10 Intrabody [Tat] | FACS, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0433MZ | Mouse Anti-ADAM10 Recombinant Antibody (clone 22H3) | FC, IHC-P, IP, WB | Mouse IgG1 |
| MRO-0029-CN | Rabbit Anti-ADAM10 Recombinant Antibody (clone JM32-11) | WB, IP | Rabbit IgG |
| PABS-0194 | Mouse Anti-ADAM10 Recombinant Antibody (PABS-0194) | IP, WB, FC, ELISA | Mouse IgG |
| VS3-FY2620 | Mouse Anti-ADAM10 Recombinant Antibody (VS3-FY2620) | IHC, FC, ELISA | Mouse IgG |
| VS7-HM38 | Mouse Anti-ADAM10 Recombinant Antibody (clone 6C3C7) | IHC, FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0068 | Hi-Affi™ Rabbit Anti-ADAM10 Recombinant Antibody (clone DS68AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0101-YJ-S(P) | Mouse Anti-ADAM10 Recombinant Antibody; scFv Fragment (HPAB-0101-YJ-S(P)) | IP, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0101-YJ-F(E) | Mouse Anti-ADAM10 Recombinant Antibody; Fab Fragment (HPAB-0101-YJ-F(E)) | IP, Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY40 | Anti-ADAM10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY146 | Anti-Mouse ADAM10 Immunohistochemistry Kit | IHC | |
| VS-0525-XY145 | Anti-Human ADAM10 Immunohistochemistry Kit | IHC |
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