Recombinant Anti-human ADAM10 Intrabody [Tat] (CAT#: IAB-B003(T))

• Immunogen
• human ADAM metallopeptidase domain 10

• Host Species
• human

• Type
• scFv-Tat

• Cell Penetrating Peptide
• TAT
  TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

• Species Reactivity
• human

• Applications
• Can be useful in applications such as: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies

• Purity
• 95% by HPLC

• Storage
• 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

• Alternative Names
• ADAM10; ADAM metallopeptidase domain 10; RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717; disintegrin and metalloproteinase domain-containing protein 10; CDw156; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprote

• Gene ID
• 102

• UniProt ID
• A0A024R5U5

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