Anti-ADAM10 Intrabody [(D-Arg)9] (IAB-B003(A))
Recombinant anti-ADAM10 intrabody linked to (D-Arg)9 works within cells to bind selectively to intracellur antigen human ADAM10, expressed in E. coli cells. The anti-ADAM10 intrabodies are designed from either the polyclonal or monoclonal anti-ADAM10 antibody cDNA that encode antibodiess that recognize the enzymatically active form of Kuz and which, upon binding, inhibit ADAM10's ability to transphosphorylate.
Specifications
- Immunogen
- human ADAM metallopeptidase domain 10
- Host
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Products can be used for: Protein fragment complementation; Western blot; Functional studies
Target
- Alternative Names
- ADAM10; ADAM metallopeptidase domain 10; RAK; kuz; AD10; AD18; MADM; CD156c
- Entrez Gene ID
- 102
- UniProt ID
- A0A024R5U5
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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