Recombinant Anti-human ADAM10 Intrabody [(D-Arg)9] (CAT#: IAB-B003(A))

Recombinant anti-ADAM10 intrabody linked to (D-Arg)9 works within cells to bind selectively to intracellur antigen human ADAM10, expressed in E. coli cells. The anti-ADAM10 intrabodies are designed from either the polyclonal or monoclonal anti-ADAM10 antibody cDNA that encode antibodiess that recognize the enzymatically active form of Kuz and which, upon binding, inhibit ADAM10's ability to transphosphorylate.


Specific Inquiry
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  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human ADAM metallopeptidase domain 10
  • Host Species
  • human
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Products can be used for: Protein fragment complementation; Western blot; Functional studies

Product Property

  • Purity
  • >95%, by SDS-PAGE, under reducing conditions
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Target

  • Alternative Names
  • ADAM10; ADAM metallopeptidase domain 10; RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717; disintegrin and metalloproteinase domain-containing protein 10; CDw156; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprote

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ADAM10"

Intrabody

CAT Product Name Application Type
IAB-B003(G) Recombinant Anti-human ADAM10 Intrabody [+36 GFP] FACS, ELISA, IF, FuncS scFv-(+36GFP)
IAB-B003(T) Recombinant Anti-human ADAM10 Intrabody [Tat] FACS, ICC, FuncS scFv-Tat

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0068 Hi-Affi™ Rabbit Anti-ADAM10 Recombinant Antibody (clone DS68AB) WB, IP Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0101-YJ-S(P) Mouse Anti-ADAM10 Recombinant Antibody; scFv Fragment (HPAB-0101-YJ-S(P)) IP, Inhib, FuncS Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0101-YJ-F(E) Mouse Anti-ADAM10 Recombinant Antibody; Fab Fragment (HPAB-0101-YJ-F(E)) IP, Inhib, FuncS Mouse Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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