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ADAM10
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- Mouse Anti-ADAM10 Recombinant Antibody (HPAB-0101-YJ) (HPAB-0101-YJ)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: ELISA, IP, Inhib, FuncS
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- Derivation: Hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IP, WB, FC, ELISA
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- Mouse Anti-ADAM10 Recombinant Antibody (clone 22H3) (MOB-0433MZ)
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- Species Reactivity: human
- Type: Mouse IgG1
- Application: FC, IHC-P, IP, WB
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- Rabbit Anti-ADAM10 Recombinant Antibody (clone JM32-11) (MRO-0029-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Rabbit Anti-ADAM10 Polyclonal Antibody (MRO-1627-CN) (MRO-1627-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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- Mouse Anti-ADAM10 Recombinant Antibody (VS3-FY2620) (VS3-FY2620)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, FC, ELISA
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- Mouse Anti-ADAM10 Recombinant Antibody; scFv Fragment (HPAB-0101-YJ-S(P)) (HPAB-0101-YJ-S(P))
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- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: IP, Inhib, FuncS
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- Mouse Anti-ADAM10 Recombinant Antibody; Fab Fragment (HPAB-0101-YJ-F(E)) (HPAB-0101-YJ-F(E))
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- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: IP, Inhib, FuncS
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Anti-ADAM10 Immunohistochemistry Kit (VS-0325-XY40)
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- Species Reactivity: Human, Mouse, Rat
- Target: ADAM10
- Application: IHC
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- Species Reactivity: Human
- Target: ADAM10
- Host Animal: Mouse
- Application: ELISA, FC, Cell-uptake
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- Anti-Mouse ADAM10 Immunohistochemistry Kit (VS-0525-XY146)
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- Species Reactivity: Human, Mouse, Rat
- Target: ADAM10
- Application: IHC
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- Recombinant Anti-human ADAM10 Intrabody [(D-Arg)9] (IAB-B003(A))
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: PCA, WB, FuncS
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- Recombinant Anti-human ADAM10 Intrabody [+36 GFP] (IAB-B003(G))
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: FACS, ELISA, IF, FuncS
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- Recombinant Anti-human ADAM10 Intrabody [Tat] (IAB-B003(T))
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- Species Reactivity: human
- Type: scFv-Tat
- Application: FACS, ICC, FuncS
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For Research Use Only. Not For Clinical Use.
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes an ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-2197)
Interaction
Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells (PubMed:16239146). Interacts with the clathrin adapter AP2 complex subunits AP2A1, AP2A2, AP2B1, and AP2M1; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497). Interacts (via extracellular domain) with TSPAN33 (via extracellular domain) and (via cytoplasmic domain) with AFDN; interaction with TSPAN33 allows the docking of ADAM10 to zonula adherens through a PDZ11-dependent interaction between TSPAN33 and PLEKHA7 while interaction with AFDN locks ADAM10 at zonula adherens (PubMed:30463011). Forms a ternary complex composed of ADAM10, EPHA4 and CADH1; within the complex, ADAM10 cleaves CADH1 which disrupts adherens junctions (By similarity). Interacts with EPHA2 (By similarity). Interacts with NGF in a divalent cation-dependent manner (PubMed:20164177). Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression (PubMed:26686862, PubMed:26668317). Interacts with TSPAN5, TSPAN10, TSPAN15, TSPAN17 and TSPAN33; these interactions regulate ADAM10 substrate specificity (PubMed:26686862). Interacts with DLG1; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (PubMed:23676497). Interacts (via extracellular domain) with BACE1 (via extracellular domain) (By similarity). Interacts with FAM171A1 (PubMed:30312582). (Microbial infection) Interacts with S.aureus hly; this interaction is necessary for toxin pore formation, disruption of focal adhesions and S.aureus hly-mediated cytotoxicity.
Molecular function
Hydrolase, Metalloprotease, Protease
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