Recombinant Rabbit Anti-CTNNA1 Antibody (clone R07-7D5)
CAT#: VS3-FY422
This product is a recombinant rabbit antibody that recognizes human, mouse and rat CTNNA1 protein. It can detect a band of approximately 100 kDa (observedd molecular weight: 100 kDa).
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46119/1028_H10_1_selected.jpg
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WB
Figure 1. Recombinant Rabbit Anti-CTNNA1 Antibody (clone R07-7D5) in WB.
Western blot analysis of alpha 1-catenin in rat brain, C6, 3T3, Hela lysates using CTNNA1 Antibody.
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Specifications
- Immunogen
- A synthetic peptide of human alpha 1 Catenin
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CTNNA1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-7D5
- Applications
- Western Blot, Immunoprecipitation
- Conjugate
- Unconjugated
- MW
- Calculated MW: 100 kDa; Observed MW: 100 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Catenin Alpha 1; Renal Carcinoma Antigen NY-REN-13; Alpha-E-Catenin; Catenin (Cadherin-Associated Protein), Alpha 1 (102kD); Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa; Cadherin-Associated Protein
- Gene ID
- 1495
- UniProt ID
- P35221
- Sequence Similarities
- Belongs to the vinculin/alpha-catenin family.
- Cellular Localization
- Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane
- Post Translation Modifications
- Sumoylated.
Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
- Protein Refseq
- NP_001277236.1; NP_001277238.1; NP_001277239.1
- Function
- Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).
May play a crucial role in cell differentiation.
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CTNNA1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2020z | Mouse Anti-CTNNA1 Recombinant Antibody (clone 5G7) | WB, FC, ICC, IF | Mouse IgG1 |
| MOB-0582MZ | Recombinant Mouse Anti-Human CTNNA1 Antibody (clone 36C2) | IHC-Fr, IHC-P, WB | Mouse antibody |
| MRO-0062-CN | Rabbit Anti-CTNNA1 Recombinant Antibody (clone CBACN-021) | WB, IF, IHC, IP, FC | Rabbit IgG |
| VS3-CJ890 | Rabbit Anti-CTNNA1 Recombinant Antibody (VS3-CJ890) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS7-HM785 | Mouse Anti-CTNNA1 Recombinant Antibody (clone 8B6C1) | IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0084MZ | Chicken Anti-α-1-Catenin (ab1) Polyclonal IgY | WB | Chicken antibody |
| BRD-0085MZ | Chicken Anti-α-1-Catenin (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0856 | Hi-Affi™ Rabbit Anti-CTNNA1 Recombinant Antibody (clone DS856AB) | WB, FC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY64 | Rabbit Anti-NHP CTNNA1 Recombinant Antibody (VS-1024-XY64) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY574 | Anti-CTNNA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1766 | Anti-Human CTNNA1 Immunohistochemistry Kit | IHC |
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