Recombinant Anti-DSG2 Vesicular Antibody, EV Displayed (VS-0425-YC466)
CAT#: VS-0425-YC466
The Recombinant Anti-DSG2 Vesicular Antibody, EV Displayed (VS-0425-YC466) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to DSG2-expressed cells or tissues. The DSG2 is a desmoglein protein crucial for desmosome formation, with mutations linked to cardiac dysplasia.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4896/1685_D1_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/672_G5_4_selected.jpg
Normal Tissue
Figure 3 Rectum
High expression in rectum
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4896/15170_A_6_3_val_selected.jpg
Normal Tissue
Figure 4 Small intestine
High expression in small intestine
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/55672_A_6_2_val_selected.jpg
Normal Tissue
Figure 5 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/55672_A_8_5.jpg
Normal Tissue
Figure 6 Parathyroid gland
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/55672_A_1_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, HBEC3-KT, hTERT-HME1, OE19)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000046604-DSG2
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- DSG2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Desmoglein 2
- Biological Process
- Cell adhesion
- Cellular Localization
- Cell Junctions
- Introduction
- This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]
- Alternative Names
- CDHF5
- Gene ID
- 1829
- UniProt ID
- Q14126
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1054 | Hi-Affi™ Rabbit Anti-DSG2 Recombinant Antibody (clone DS1054AB) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0063-YC-S(P) | Mouse Anti-DSG2 Recombinant Antibody; scFv Fragment (HPAB-N0063-YC-S(P)) | FC, WB | Mouse scFv |
| HPAB-N0064-YC-S(P) | Mouse Anti-DSG2 Recombinant Antibody; scFv Fragment (HPAB-N0064-YC-S(P)) | FC, WB | Mouse scFv |
| HPAB-0405-FY-S(P) | Human Anti-DSG2 Recombinant Antibody; scFv Fragment (HPAB-0405-FY-S(P)) | FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0063-YC-F(E) | Mouse Anti-DSG2 Recombinant Antibody; Fab Fragment (HPAB-N0063-YC-F(E)) | FC, WB | Mouse Fab |
| HPAB-N0064-YC-F(E) | Mouse Anti-DSG2 Recombinant Antibody; Fab Fragment (HPAB-N0064-YC-F(E)) | FC, WB | Mouse Fab |
| HPAB-0405-FY-F(E) | Human Anti-DSG2 Recombinant Antibody; Fab Fragment (HPAB-0405-FY-F(E)) | FC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY80 | AbPlus™ Anti-DSG2 Magnetic Beads (10D2) | IP, Protein Purification | |
| VS-0724-YC1365 | AbPlus™ Anti-DSG2 Magnetic Beads (VS-0724-YC1365) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY101 | CytoStream™ Mouse Anti-DSG2 Recombinant Antibody (clone 6D8) | FC | Mouse IgG1, kappa |
| VS13-YC325 | CytoStream™ Rabbit Anti-DSG2 Recombinant Antibody (VS13-YC325) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY699 | Anti-DSG2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2094 | Anti-Human DSG2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY21 | Human Anti-DSG2 scFv-Fc Chimera (VS-0425-FY21) | FC, IP | Human IgG1, scFv-Fc |
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