DSG2

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Distal enterocytes, Pancreatic endocrine cells, Undifferentiated cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enhanced (CAPAN-2, HaCaT, HBEC3-KT, hTERT-HME1, OE19)

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