Human Anti-DSG2 scFv-Fc Chimera (VS-0425-FY21)
CAT#: VS-0425-FY21
This anti-DSG2 scFv-Fc antibody is designed to specifically target desmoglein 2 (Dsg2), a crucial transmembrane glycoprotein found within desmosomal junctions. Given the unique expression of Dsg2 on undifferentiated human pluripotent stem cells, this antibody serves as a valuable tool for their precise detection and isolation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4896/1685_D1_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/672_G5_4_selected.jpg
Normal Tissue
Figure 3 Rectum
High expression in rectum
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4896/15170_A_6_3_val_selected.jpg
Normal Tissue
Figure 4 Small intestine
High expression in small intestine
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/55672_A_6_2_val_selected.jpg
Normal Tissue
Figure 5 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/55672_A_8_5.jpg
Normal Tissue
Figure 6 Parathyroid gland
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25122/55672_A_1_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, HaCaT, HBEC3-KT, hTERT-HME1, OE19)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000046604-DSG2
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Specifications
- Immunogen
- The immunogen is the H9 cell line.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human DSG2
- Species Reactivity
- Human
- Applications
- Flow Cytometry, Immunoprecipitation
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Desmoglein 2; Cadherin Family Member 5; CDHF5; HDGC; Desmoglein-2
- Gene ID
- 1829
- UniProt ID
- Q14126
- Long Name
- Desmoglein 2
- Cellular Localization
- Cell membrane, Cell junction, desmosome
- Post Translation Modifications
- Palmitoylated by ZDHHC5 at the plasma membrane.
Glycosylation at Asn112, Asn182, Asn309, Asn462, Asn514, and Asn789
Ubiquitination at Lys706, Lys746, and Lys832
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect DSG2_HUMAN (1172)
Glycosylation from GlyGen 12 sites, 40 N-linked glycans (5 sites), 2 O-linked glycans (3 sites)
- Protein Refseq
- XP_047293271.1; XP_054174212.1; NP_001934.2
- Function
- Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3317z | Mouse Anti-DSG2 Recombinant Antibody (clone 19F5) | WB, IP, IF | Mouse IgG1, κ |
| MOB-2195MZ | Recombinant Mouse Anti-Human DSG2 Antibody (clone 4H243) | ICC, IF, IHC-P, IP, WB | Mouse antibody |
| HPAB-N0063-YC | Mouse Anti-DSG2 Recombinant Antibody (HPAB-N0063-YC) | FC, WB | Mouse IgG |
| HPAB-N0064-YC | Mouse Anti-DSG2 Recombinant Antibody (HPAB-N0064-YC) | FC, WB | Mouse IgG |
| HPAB-0405-FY | Human Anti-DSG2 Recombinant Antibody (HPAB-0405-FY) | FC, IP | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1054 | Hi-Affi™ Rabbit Anti-DSG2 Recombinant Antibody (clone DS1054AB) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0063-YC-S(P) | Mouse Anti-DSG2 Recombinant Antibody; scFv Fragment (HPAB-N0063-YC-S(P)) | FC, WB | Mouse scFv |
| HPAB-N0064-YC-S(P) | Mouse Anti-DSG2 Recombinant Antibody; scFv Fragment (HPAB-N0064-YC-S(P)) | FC, WB | Mouse scFv |
| HPAB-0405-FY-S(P) | Human Anti-DSG2 Recombinant Antibody; scFv Fragment (HPAB-0405-FY-S(P)) | FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0063-YC-F(E) | Mouse Anti-DSG2 Recombinant Antibody; Fab Fragment (HPAB-N0063-YC-F(E)) | FC, WB | Mouse Fab |
| HPAB-N0064-YC-F(E) | Mouse Anti-DSG2 Recombinant Antibody; Fab Fragment (HPAB-N0064-YC-F(E)) | FC, WB | Mouse Fab |
| HPAB-0405-FY-F(E) | Human Anti-DSG2 Recombinant Antibody; Fab Fragment (HPAB-0405-FY-F(E)) | FC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY80 | AbPlus™ Anti-DSG2 Magnetic Beads (10D2) | IP, Protein Purification | |
| VS-0724-YC1365 | AbPlus™ Anti-DSG2 Magnetic Beads (VS-0724-YC1365) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY101 | CytoStream™ Mouse Anti-DSG2 Recombinant Antibody (clone 6D8) | FC | Mouse IgG1, kappa |
| VS13-YC325 | CytoStream™ Rabbit Anti-DSG2 Recombinant Antibody (VS13-YC325) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY699 | Anti-DSG2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2094 | Anti-Human DSG2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC466 | Recombinant Anti-DSG2 Vesicular Antibody, EV Displayed (VS-0425-YC466) | ELISA, FC, Cell-uptake |
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