Recombinant Anti-EPHA2 Vesicular Antibody, EV Displayed (VS-0425-YC564)

Name: Recombinant Anti-EPHA2 Vesicular Antibody, EV Displayed (VS-0425-YC564)
SKU: VS-0425-YC564
Rating: 5 (1 reviews)

CAT#: VS-0425-YC564

The Recombinant Anti-EPHA2 Vesicular Antibody, EV Displayed (VS-0425-YC564) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EPHA2-expressed cells or tissues. EPHA2, part of the ephrin receptor family, plays roles in nervous system development and certain cataract disorders. Mutations affect binding and receptor function.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg

RNA Expression Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2

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Recombinant Antibody

Application
ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
EPHA2

Host Animal
Mouse

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
Protein A

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
EPH receptor A2

Biological Process
Angiogenesis, Apoptosis, Cell adhesion, Differentiation, Host-virus interaction

Molecular Function
Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Cellular Localization
Plasma membrane, Cell Junctions, Nuclear speckles, Golgi apparatus

Introduction
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.

Alternative Names
ECK

Gene ID
1969

UniProt ID
P29317

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Datasheet

Datasheet - VS-0425-YC564.pdf

MSDS

MSDS - VS-0425-YC564.pdf

COA

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