Recombinant Anti-EPHA2 Vesicular Antibody, EV Displayed (VS-0425-YC564)

CAT#: VS-0425-YC564

The Recombinant Anti-EPHA2 Vesicular Antibody, EV Displayed (VS-0425-YC564) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EPHA2-expressed cells or tissues. EPHA2, part of the ephrin receptor family, plays roles in nervous system development and certain cataract disorders. Mutations affect binding and receptor function.

Gene Expression
Figure 1 IF staining of human cell line A549 Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • EPHA2
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • EPH receptor A2
  • Biological Process
  • Angiogenesis, Apoptosis, Cell adhesion, Differentiation, Host-virus interaction
  • Molecular Function
  • Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase
  • Cellular Localization
  • Plasma membrane, Cell Junctions, Nuclear speckles, Golgi apparatus
  • Introduction
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
  • Alternative Names
  • ECK
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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