Human Anti-EPHA2 (clone 3F2) scFv-Fc Chimera (CAT#: VS-0325-FY81)
The anti-EPHA2 scFv-Fc antibody targets EPHA2, a receptor tyrosine kinase involved in angiogenesis, cell migration, and cancer progression. It can modulate EPHA2 signaling, potentially affecting vascular and tumor biology. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EPHA2
- Species Reactivity
- Human
- Clone
- 3F2
- Applications
- ELISA, Immunofluorescence, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase
- Gene ID
- 1969
- UniProt ID
- P29317
- Long Name
- EPH Receptor A2
- Sequence Similarities
- Belongs to the ephrin receptor subfamily.
- Cellular Localization
- Cell membrane; Cell projection; ruffle membrane; Cell projection; lamellipodium membrane; Cell junction; focal adhesion
- Post Translation Modifications
- Autophosphorylates.
Ubiquitinated by CHIP/STUB1.
Glycosylation at Asn407 and Asn435
Ubiquitination at Lys578
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect EPHA2_HUMAN (777)
Glycosylation from GlyGen 4 sites, 4 N-linked glycans (1 site), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_016856026.1; XP_047304215.1; XP_047304223.1; XP_047304228.1; XP_054190833.1
- Function
- Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-083 | Human Anti-EPHA2 Recombinant Antibody (clone 1C1); scFv Fragment | ELISA, WB, FuncS | Human scFv |
| HPAB-M0068-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone D2-1A7); scFv Fragment | Inhib | Human scFv |
| HPAB-M0069-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone TS1); scFv Fragment | FC | Human scFv |
| HPAB-M0070-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone Ab2); scFv Fragment | FC | Human scFv |
| HPAB-M0071-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone Ab3); scFv Fragment | FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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