Human Anti-EPHA2 (clone 3F2) scFv-Fc Chimera

CAT#: VS-0325-FY81

The anti-EPHA2 scFv-Fc antibody targets EPHA2, a receptor tyrosine kinase involved in angiogenesis, cell migration, and cancer progression. It can modulate EPHA2 signaling, potentially affecting vascular and tumor biology. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.

Gene Expression
Figure 1 IF staining of human cell line A549 Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human EPHA2
  • Species Reactivity
  • Human
  • Clone
  • 3F2
  • Applications
  • ELISA, Immunofluorescence, Flow Cytometry
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase
  • Long Name
  • EPH Receptor A2
  • Sequence Similarities
  • Belongs to the ephrin receptor subfamily.
  • Cellular Localization
  • Cell membrane; Cell projection; ruffle membrane; Cell projection; lamellipodium membrane; Cell junction; focal adhesion
  • Post Translation Modifications
  • Autophosphorylates.
    Ubiquitinated by CHIP/STUB1.
    Glycosylation at Asn407 and Asn435
    Ubiquitination at Lys578
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect EPHA2_HUMAN (777)
    Glycosylation from GlyGen 4 sites, 4 N-linked glycans (1 site), 2 O-linked glycans (2 sites)
  • Function
  • Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
    Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
    Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells.
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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

Secondary Antibody

See other products for "Clone 3F2"

See other products for "EPHA2"

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VS-0724-XY25 Rabbit Anti-EPHA2 Agonistic Antibody (VS-0724-XY25) WB, ELISA, FC, IF, Agonistic assays Rabbit IgG, kappa
VS-0724-XY26 Human Anti-EPHA2 Agonistic Antibody (clone 1C1) WB, ELISA, FC, IF, Agonistic assays Human IgG1, kappa
CAT Product Name Application Type
VS-0424-XY87 AbPlus™ Anti-EPHA2 Magnetic Beads (VS-0424-XY87) IP, Protein Purification
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