Human Anti-EPHA2 (clone 3F2) scFv-Fc Chimera
CAT#: VS-0325-FY81
The anti-EPHA2 scFv-Fc antibody targets EPHA2, a receptor tyrosine kinase involved in angiogenesis, cell migration, and cancer progression. It can modulate EPHA2 signaling, potentially affecting vascular and tumor biology. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EPHA2
- Species Reactivity
- Human
- Clone
- 3F2
- Applications
- ELISA, Immunofluorescence, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase
- Gene ID
- 1969
- UniProt ID
- P29317
- Long Name
- EPH Receptor A2
- Sequence Similarities
- Belongs to the ephrin receptor subfamily.
- Cellular Localization
- Cell membrane; Cell projection; ruffle membrane; Cell projection; lamellipodium membrane; Cell junction; focal adhesion
- Post Translation Modifications
- Autophosphorylates.
Ubiquitinated by CHIP/STUB1.
Glycosylation at Asn407 and Asn435
Ubiquitination at Lys578
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect EPHA2_HUMAN (777)
Glycosylation from GlyGen 4 sites, 4 N-linked glycans (1 site), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_016856026.1; XP_047304215.1; XP_047304223.1; XP_047304228.1; XP_054190833.1
- Function
- Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 3F2"
- CAT
- Product Name
See other products for "EPHA2"
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| CAT | Product Name | Application | Type |
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| TAB-385MZ | Human Anti-EPHA2 Recombinant Antibody (TAB-385MZ) | ELISA | Humanized IgG |
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| MHC-LC145 | PE-A*02:01/Human EphA2 (TLADFDPRV) MHC Tetramer | FCM | |
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| CAT | Product Name | Application | Type |
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| HPAB-0336-YC-S(P) | Mouse Anti-EPHA2 Recombinant Antibody; scFv Fragment (HPAB-0336-YC-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| HPAB-0337-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody; scFv Fragment (HPAB-0337-YC-S(P)) | ELISA, FC, FuncS | Humanized scFv |
| HPAB-0338-YC-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone 2E7); scFv Fragment | ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
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