Recombinant Rabbit Anti-FLT4 Detection Antibody (clone R12-4S-1) (CAT#: VS3-WK1957)

• Immunogen
• Recombinant human FLT4 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human FLT4

• Species Reactivity
• Human

• Clone
• R12-4S-1

• Applications
• ELISA

• Conjugate
• Unconjugated

• Clonality
• Monoclonal

• Purification
• Protein A affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Aggregation
• < 5%

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 0.01M PBS, pH 7.2

• Storage
• Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Fms Related Tyrosine Kinase 4; Tyrosine-Protein Kinase Receptor FLT4; Fms-Like Tyrosine Kinase 4; EC 2.7.10.1; VEGFR-3; VEGFR3; FLT-4

• Gene ID
• 2324

• UniProt ID
• P35916

• Long Name
• Fms Related Tyrosine Kinase 4

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

• Post Translation Modifications
• Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation in response to H2O2 is mediated by a process that requires SRC and PRKCD activity. Phosphorylation at Tyr-1068 is required for autophosphorylation at additional tyrosine residues. Phosphorylation at Tyr-1063 and Tyr-1337 is important for interaction with CRK and subsequent activation of MAPK8. Phosphorylation at Tyr-1230, Tyr-1231 and Tyr-1337 is important for interaction with GRB2 and subsequent activation of the AKT1 and MAPK1/ERK2 and/or MAPK3/ERK1 signaling pathways. In response to endothelial cell adhesion onto collagen, can also be phosphorylated in the absence of FLT4 kinase activity by SRC at Tyr-830, Tyr-833, Tyr-853, Tyr-1063, Tyr-1333, and Tyr-1337.

• Protein Refseq
• NP_002011.2

• Function
• Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling.

Capture antibody

• VS3-WK1956
• Recombinant Rabbit Anti-FLT4 Capture Antibody (clone R56-2B-3)

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2RD-A1517-YJ
• Sheep Anti-Rabbit IgG-heavy and light chain Secondary antibody

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