Recombinant Anti-GHR Vesicular Antibody, EV Displayed (VS-0425-YC190)
CAT#: VS-0425-YC190
The Recombinant Anti-GHR Vesicular Antibody, EV Displayed (VS-0425-YC190) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GHR-expressed cells or tissues. The GHR is a receptor for growth hormone, leading to signal transduction pathways that promote growth. Mutations are associated with Laron syndrome, characterized by short stature. Humans and rabbits generate growth hormone binding protein through proteolytic cleavage of this receptor.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1366_E6_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane, cytosol & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1639_F9_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane, cytosol & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1361_E6_2_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Enterocytes - Microvilli
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (microvilli)
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (HSkMC, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112964-GHR
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GHR
- Host Animal
- Mouse
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Growth hormone receptor
- Biological Process
- Endocytosis
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Cytosol, Cytoplasmic bodies
- Introduction
- This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
- Alternative Names
- GHBP
- Gene ID
- 2690
- UniProt ID
- P10912
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-089CQ | Anti-Human GHR Recombinant Antibody (Ab13) | ELISA, FC | |
| TAB-089CQ-S(P) | Anti-Human GHR Recombinant Antibody scFv Fragment (Ab13) | ELISA, FC | |
| TAB-089CQ-F(E) | Anti-Human GHR Recombinant Antibody Fab Fragment (Ab13) | ELISA, FC | |
| TAB-262CQ | Anti-Human GHR Recombinant Antibody (GF185) | FC, IP, Inhib | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-090CQ | Anti-Human GHR Recombinant Antibody (SS1) | ELISA, FC | Humanized antibody |
| TAB-090CQ-S(P) | Anti-Human GHR Recombinant Antibody scFv Fragment (SS1) | ELISA, FC | Humanized antibody |
| TAB-091CQ-S(P) | Anti-Human GHR Recombinant Antibody scFv Fragment (SS3) | ELISA, FC | Humanized antibody |
| TAB-090CQ-F(E) | Anti-Human GHR Recombinant Antibody Fab Fragment (SS1) | ELISA, FC | Humanized antibody |
| TAB-091CQ-F(E) | Anti-Human GHR Recombinant Antibody Fab Fragment (SS3) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-875CQ | Mouse Anti-GHR Recombinant Antibody (clone CBL068) | WB, Neut | Mouse IgG2 |
| NEUT-876CQ | Mouse Anti-GHR Recombinant Antibody (clone CBL584) | WB, Neut | Mouse IgG2b |
| NEUT-877CQ | Mouse Anti-GHR Recombinant Antibody (clone MM0320-6J33) | WB, Neut | Mouse IgG2 |
| NEUT-878CQ | Mouse Anti-GHR Recombinant Antibody (clone MM0321-3C59) | WB, Neut | Mouse IgG2 |
| NEUT-879CQ | Mouse Anti-Ghr Recombinant Antibody (clone CBL586) | WB, Neut | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1438 | Hi-Affi™ Rabbit Anti-GHR Recombinant Antibody (clone DS1438AB) | WB, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY110 | AbPlus™ Anti-GHR Magnetic Beads (GF185) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2800 | Anti-Mouse GHR Immunohistochemistry Kit | IHC |
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