Anti-Human GHR Recombinant Antibody (GF185) (CAT#: TAB-262CQ)
Recombinant monoclonal antibody to GHR. This antibody binds to epitopes that are localized within subdomain 1 of GHR-ECD and is able to neutralize growth hormone (GH) signalling and inhibit GH-induced Ba/F3-GHR proliferation.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1366_E6_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1366_E6_2_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1639_F9_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1639_F9_2_blue_red_green.jpg
Figure 3 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1361_E6_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane, cytosol & cytoplasmic bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1361_E6_2_blue_red_green.jpg
Figure 4 Colon
(Enterocytes - Microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_7_3.jpg
(Enterocytes - Microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_7_3.jpg
Figure 5 Liver
(Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_8_4.jpg
(Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_8_4.jpg
Figure 6 Kidney
(Collecting ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (microvilli)
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_9_5.jpg
(Collecting ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (microvilli)
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_9_5.jpg
Figure 7 Testis
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_4_6.jpg
(Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45339/162625_A_4_6.jpg
Figure 8 RNA cell line category: Group enriched (HSkMC, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112964-GHR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112964-GHR
Specifications
- Immunogen
- GHBP
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- GF185
- Applications
- FC, IP, Inhib
- Related Disease
- GH-dependent disease
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Immunoprecipitation, Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- GHR; growth hormone receptor; GHBP; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
- Gene ID
- 2690
- UniProt ID
- P10912
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1090-VHH | Recombinant Anti-Human GHR VHH Single Domain Antibody | FA, FC, ICC, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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