AbPlus™ Anti-GHR Magnetic Beads (GF185)
CAT#: VS-0424-XY110
The AbPlus Anti-GHR Magnetic Beads (GF185) is an innovative affinity resin which is bound with anti-GHR specific antibody (GF185). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of GHR protein under native and denaturing conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & cytoplasmic bodies.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57705/1366_E6_2_selected.jpg
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-GHR specific antibody (GF185)
- Target
- GHR
- Immunogen
- Human GHBP protein
- Target Species
- Human
- Antibody Clone
- GF185
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
- Alternative Names
- GHR; growth hormone receptor; GHBP; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
- Gene ID
- 2690
- UniProt ID
- P10912
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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