AbPlus™ Anti-GHR Magnetic Beads (GF185)

CAT#: VS-0424-XY110

The AbPlus Anti-GHR Magnetic Beads (GF185) is an innovative affinity resin which is bound with anti-GHR specific antibody (GF185). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of GHR protein under native and denaturing conditions.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IF staining of human cell line HEK 293 Figure 3 IF staining of human cell line SK-MEL-30 Figure 4 Colon Figure 5 Liver Figure 6 Kidney Figure 7 Testis Figure 8 RNA cell line category: Group enriched (HSkMC, T-47d)

Specifications

  • Applications
  • Immunoprecipitation, Protein Purification
  • Matrix
  • Magrose bead (> 50 μmol/mL gel)
  • Bead Ligand
  • Anti-GHR specific antibody (GF185)
  • Target
  • GHR
  • Immunogen
  • Human GHBP protein
  • Target Species
  • Human
  • Antibody Clone
  • GF185
  • Bead Capacity
  • 20-30 mg/mL binding antibody
  • Bead size
  • 10-37 μm
  • Stability
  • pH 2-14
  • Format
  • 20% Suspension
  • Buffer
  • PBS, pH 7.4, with 1% BSA
  • Preservative
  • 0.03% Proclin 300
  • Storage
  • Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

  • Application Notes
  • The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

  • Introduction
  • This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
  • Alternative Names
  • GHR; growth hormone receptor; GHBP; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
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