Recombinant Anti-ICAM1 Vesicular Antibody, EV Displayed (VS-0425-YC540)

Name: Recombinant Anti-ICAM1 Vesicular Antibody, EV Displayed (VS-0425-YC540)
SKU: VS-0425-YC540
Rating: 5 (1 reviews)

CAT#: VS-0425-YC540

The Recombinant Anti-ICAM1 Vesicular Antibody, EV Displayed (VS-0425-YC540) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ICAM1-expressed cells or tissues. ICAM1 is a cell surface glycoprotein expressed on immune and endothelial cells, binding integrins used by Rhinovirus as a receptor.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/29_G3_2_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2142/203_G3_1_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line EFO-21

Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/1937_A10_1_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 4 IF staining of human cell line GAMG

Immunofluorescent staining of human cell line GAMG shows localization to plasma membrane, vesicles, nucleoplasm & centrosome.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/2058_A10_4_blue_red_green.jpg

Normal Tissue Figure 5 Cerebral cortex

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/7230_B_9_5.jpg

Normal Tissue Figure 6 Lung

Alveolar cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/7230_A_3_4.jpg

Normal Tissue Figure 7 Colon

Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_8_3.jpg

Normal Tissue Figure 8 Kidney

Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_8_5.jpg

Normal Tissue Figure 9 Lymph node

Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_9_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enhanced (HHSteC, Karpas-707, RPMI-8226)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090339-ICAM1

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
ICAM1

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Intercellular adhesion molecule 1

Biological Process
Cell adhesion, Host-virus interaction

Molecular Function
Host cell receptor for virus entry, Receptor

Cellular Localization
Plasma membrane, Vesicles, Cytosol

Introduction
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.

Alternative Names
BB2, CD54

Gene ID
3383

UniProt ID
P05362

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Related Diseases

Rheumatoid Arthritis

AGE-RAGE Signaling Pathway in Diabetic Complications

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0425-YC540.pdf

MSDS

MSDS - VS-0425-YC540.pdf

COA

Certificate of Analysis Lookup

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TAB-124CT-S(P)	Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (m1A6)	ELISA
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AGTO-L023R	anti-ICAM1 immunotoxin UV3 (IgG)-RTA	Cytotoxicity assay, Functional assay

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TAB-123CT	Anti-Human ICAM-1 Recombinant Antibody (h1A6)	ELISA	Humanized antibody
TAB-123CT-S(P)	Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (h1A6)	ELISA	Humanized antibody
TAB-123CT-F(E)	Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (h1A6)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
TAB-121CT-S(P)	Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (MD-2)	ELISA, FC	Human antibody
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TAB-121CT-F(E)	Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (MD-2)	ELISA, FC	Human antibody
TAB-122CT-F(E)	Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (R6-5-D6)	ELISA, FC	Human antibody
TAB-125CT-F(E)	Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (ICM 10064)	Inhibit, ELISA, WB	Human antibody

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CAT	Product Name	Application	Type
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NEUT-927CQ	Mouse Anti-ICAM1 Recombinant Antibody (NEUT-927CQ)	FC, IF, IHC, Neut, WB, ELISA	Mouse IgG1
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CAT	Product Name	Application	Type
MOR-1723	Rabbit Anti-ICAM1 Recombinant Antibody (clone DS1723AB), Biotin	IHC-Fr, IP, WB, ELISA	Rabbit IgG
MOR-1724	Rabbit Anti-Icam1 Recombinant Antibody (clone DS1724AB)	ELISA	Rabbit IgG
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HPAB-0053-YC-S(P)	Human Anti-ICAM1 Recombinant Antibody scFv Fragment (HPAB-0053-YC-S(P))	FC, IP	Human scFv
HPAB-0043-FY-S(P)	Human Anti-ICAM1 Recombinant Antibody scFv Fragment (HPAB-0043-FY-S(P))	ELISA	Human scFv
HPAB-1728-FY-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone LAC1555); scFv Fragment	ELISA	Human scFv
HPAB-1729-FY-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone LAC3040); scFv Fragment	ELISA	Human scFv
HPAB-1730-FY-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone LAC3041); scFv Fragment	ELISA	Human scFv

CAT	Product Name	Application	Type
EPAF-1635LC	Mouse Anti-ICAM1 Recombinant Antibody (clone c78.4A)	FC	Mouse IgG

CAT	Product Name	Application	Type
HPAB-0859-CN-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone BI-AB); Fab Fragment	ELISA, FC, Neut	Human Fab
HPAB-662-FY-F(E)	Human Anti-ICAM1 Recombinant Antibody Fab Fragment (HPAB-662-FY-F(E))	Inhib	Human Fab
HPAB-S0062-YC-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone HumB); Fab Fragment	ELISA, FuncS	Humanized Fab
HPAB-S0063-YC-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone HumC); Fab Fragment	ELISA, FuncS	Humanized Fab
HPAB-S0064-YC-F(E)	Human Anti-ICAM1 Recombinant Antibody (clone HumD); Fab Fragment	ELISA, FuncS	Humanized Fab

CAT	Product Name	Application	Type
MRO-0805-CN	Mouse Anti-ICAM1 Recombinant Antibody (clone F11-A4)	WB, IF, IHC	Mouse IgG1a
MRO-0806-CN	Mouse Anti-ICAM1 Recombinant Antibody (clone J0-F7)	WB, IF, IHC, FC	Mouse IgG2a
MRO-0807-CN	Rabbit Anti-ICAM1 Recombinant Antibody (clone CBACN-298)	WB, IF, IHC	Rabbit IgG
ZG-0122J	Mouse Anti-ICAM1 Recombinant Antibody (ZG-0122J)	IHC-P, IF	Mouse IgG
ZG-0123J	Mouse Anti-ICAM1 Recombinant Antibody (ZG-0123J)	IHC-P, IF	Mouse IgG

CAT	Product Name	Application	Type
VS-0424-XY141	AbPlus™ Anti-ICAM1 Magnetic Beads (15.2)	IP, Protein Purification
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
VS-0225-XY121	CytoStream™ Mouse Anti-ICAM1 Recombinant Antibody (clone HA58)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
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VS-0525-XY3370	Anti-Rat ICAM1 Immunohistochemistry Kit	IHC

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