Recombinant Anti-ICAM1 Vesicular Antibody, EV Displayed (VS-0425-YC540)
CAT#: VS-0425-YC540
The Recombinant Anti-ICAM1 Vesicular Antibody, EV Displayed (VS-0425-YC540) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ICAM1-expressed cells or tissues. ICAM1 is a cell surface glycoprotein expressed on immune and endothelial cells, binding integrins used by Rhinovirus as a receptor.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/29_G3_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2142/203_G3_1_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/1937_A10_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line GAMG
Immunofluorescent staining of human cell line GAMG shows localization to plasma membrane, vesicles, nucleoplasm & centrosome.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/2058_A10_4_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/7230_B_9_5.jpg
Normal Tissue
Figure 6 Lung
Alveolar cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/7230_A_3_4.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_8_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_8_5.jpg
Normal Tissue
Figure 9 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HHSteC, Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090339-ICAM1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ICAM1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Intercellular adhesion molecule 1
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Plasma membrane, Vesicles, Cytosol
- Introduction
- This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
- Alternative Names
- BB2, CD54
- Gene ID
- 3383
- UniProt ID
- P05362
REVIEWS AND Q&AS
CITATIONS
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Related Diseases
Rheumatoid Arthritis
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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|---|---|---|---|
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| TAB-126CT | Llama Anti-ICAM1 Recombinant Antibody (TAB-126CT) | ELISA, IF | Llama VHH |
| HPAB-0349-YC-VHH | Recombinant Llama Anti-ICAM1 Single Domain Antibody (HPAB-0349-YC-VHH) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-241 | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (TAB-241) | WB, IF, IP, Neut, FuncS, ELISA, FC | Fab' - G2a |
| TAB-H26 | Anti-Human ICAM1 Recombinant Antibody (TAB-H26) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG2a |
| TAB-124CT | Anti-Human ICAM-1 Recombinant Antibody (m1A6) | ELISA | |
| TAB-124CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (m1A6) | ELISA | |
| TAB-124CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (m1A6) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L023R | anti-ICAM1 immunotoxin UV3 (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-079 | Mouse Anti-ICAM1 Recombinant Antibody (clone CA7); Fab Fragment | FC | Mouse Fab |
| HPAB-0053-YC-F(E) | Human Anti-ICAM1 Recombinant Antibody Fab Fragment (HPAB-0053-YC-F(E)) | FC, IP | Human Fab |
| HPAB-0043-FY-F(E) | Human Anti-ICAM1 Recombinant Antibody Fab Fragment (HPAB-0043-FY-F(E)) | ELISA | Human Fab, λ |
| HPAB-1728-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone LAC1555); Fab Fragment | ELISA | Human Fab |
| HPAB-1729-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone LAC3040); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-079 | Mouse Anti-ICAM1 Recombinant Antibody (clone CA7); scFv Fragment | FC | Mouse scFv |
| HPAB-0043-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody scFv Fragment (HPAB-0043-FY-S(P)) | ELISA | Human scFv |
| HPAB-0859-CN-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone BI-AB); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-S0062-YC-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone HumB); scFv Fragment | ELISA, FuncS | Humanized scFv |
| HPAB-S0063-YC-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone HumC); scFv Fragment | ELISA, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-121CT | Anti-Human ICAM-1 Recombinant Antibody (MD-2) | ELISA, FC | Human antibody |
| TAB-122CT | Anti-Human ICAM-1 Recombinant Antibody (R6-5-D6) | ELISA, FC | Human antibody |
| TAB-125CT | Anti-Human ICAM-1 Recombinant Antibody (ICM 10064) | Inhibit, ELISA, WB | Human antibody |
| TAB-121CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (MD-2) | ELISA, FC | Human antibody |
| TAB-122CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (R6-5-D6) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-123CT | Anti-Human ICAM-1 Recombinant Antibody (h1A6) | ELISA | Humanized antibody |
| TAB-123CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (h1A6) | ELISA | Humanized antibody |
| TAB-123CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (h1A6) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-104LC | Recombinant Anti-Human ICAM1 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-923CQ | Mouse Anti-ICAM1 Recombinant Antibody (clone CBL236) | Neut, IF, FC, WB, IHC | Mouse IgG1 |
| NEUT-925CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-925CQ) | FC, FuncS, IHC, Neut, WB | Mouse IgG1, κ |
| NEUT-926CQ | Mouse Anti-ICAM1 Recombinant Antibody (VMC182) | FC, IF, IHC, ICC, Neut | Mouse IgG2b |
| NEUT-932CQ | Rat Anti-Icam1 Recombinant Antibody (clone YN1/1.7.4) | WB, Neut, FC, IHC, IHC-Fr, IP, ICC | Rat IgG2b, κ |
| NEUT-933CQ | Mouse Anti-Icam1 Recombinant Antibody (clone 1A29) | WB, IP, ICC, IF, IHC-P, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-924CQ | Mouse Anti-ICAM1 Recombinant Antibody (clone HCD54) | FC, IF, Block | Mouse IgG1, κ |
| NEUT-928CQ | Mouse Anti-ICAM1 Recombinant Antibody (VMC183) | Block, FC, IHC, IP | Mouse IgG1 |
| NEUT-929CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-929CQ) | Block, WB, IP, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1723 | Rabbit Anti-ICAM1 Recombinant Antibody (clone DS1723AB), Biotin | IHC-Fr, IP, WB, ELISA | Rabbit IgG |
| MOR-1724 | Rabbit Anti-Icam1 Recombinant Antibody (clone DS1724AB) | ELISA | Rabbit IgG |
| MOR-4598 | Rabbit Anti-ICAM1 Recombinant Antibody (clone TH111DS) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1635LC | Mouse Anti-ICAM1 Recombinant Antibody (clone c78.4A) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-026CQ | Mouse Anti-ICAM1 Recombinant Antibody (clone 8.4A6) | ELISA, FC, Inhib | Mouse IgG1 |
| FN-083CQ | Rat Anti-Icam1 Recombinant Antibody (clone BE29G1) | IHC-Fr, FC, IP, Block | Rat IgG2a |
| HPAB-1728-FY | Human Anti-ICAM1 Recombinant Antibody (clone LAC1555) | ELISA | Human IgG4 |
| HPAB-1729-FY | Human Anti-ICAM1 Recombinant Antibody (clone LAC3040) | ELISA | Human IgG4 |
| HPAB-1730-FY | Human Anti-ICAM1 Recombinant Antibody (clone LAC3041) | ELISA | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY141 | AbPlus™ Anti-ICAM1 Magnetic Beads (15.2) | IP, Protein Purification | |
| VS-0724-YC1353 | AbPlus™ Anti-Icam1 Magnetic Beads (VS-0724-YC1353) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY45 | Human Anti-ICAM1 (clone 1A6) scFv-Fc Chimera | ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY121 | CytoStream™ Mouse Anti-ICAM1 Recombinant Antibody (clone HA58) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3367 | Anti-Mouse ICAM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3370 | Anti-Rat ICAM1 Immunohistochemistry Kit | IHC |
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