anti-ICAM1 immunotoxin UV3 (IgG)-RTA
CAT#: AGTO-L023R
This immunotoxin was achieved by conjugating/fusing the Anti-ICAM1 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to melanoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of melanoma.










Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- UV3
- Molecule Class
- L kappa; IgG2a-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Melanoma
Target
- Alternative Names
- ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Melanoma; MM; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 3383
- UniProt ID
- P05362
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Related Diseases
Related Signaling Pathways
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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CAT | Product Name | Application | Type |
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DrMAB-1136 | Human Anti-ICAM1 Recombinant Antibody (clone YC170); scFv Fragment | ELISA, WB, IHC, IP | Human scFv |
PSBZ-079 | Mouse Anti-ICAM1 Recombinant Antibody (clone CA7); scFv Fragment | FC | Mouse scFv |
HPAB-0053-YC-S(P) | Human Anti-ICAM1 Recombinant Antibody scFv Fragment (HPAB-0053-YC-S(P)) | FC, IP | Human scFv |
HPAB-0043-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody scFv Fragment (HPAB-0043-FY-S(P)) | ELISA | Human scFv |
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CAT | Product Name | Application | Type |
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TAB-241 | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (TAB-241) | WB, IF, IP, Neut, FuncS, ELISA, FC | Fab' - G2a |
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TAB-124CT | Anti-Human ICAM-1 Recombinant Antibody (m1A6) | ELISA | |
TAB-124CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (m1A6) | ELISA | |
TAB-124CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (m1A6) | ELISA |
CAT | Product Name | Application | Type |
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TAB-121CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (MD-2) | ELISA, FC | Human antibody |
TAB-121CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (MD-2) | ELISA, FC | Human antibody |
TAB-122CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (R6-5-D6) | ELISA, FC | Human antibody |
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PFBZ-079 | Mouse Anti-ICAM1 Recombinant Antibody (clone CA7); Fab Fragment | FC | Mouse Fab |
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HPAB-1728-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone LAC1555); Fab Fragment | ELISA | Human Fab |
HPAB-1729-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone LAC3040); Fab Fragment | ELISA | Human Fab |
HPAB-1730-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone LAC3041); Fab Fragment | ELISA | Human Fab |
CAT | Product Name | Application | Type |
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TAB-123CT | Anti-Human ICAM-1 Recombinant Antibody (h1A6) | ELISA | Humanized antibody |
TAB-123CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (h1A6) | ELISA | Humanized antibody |
TAB-123CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (h1A6) | ELISA | Humanized antibody |
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Gly-104LC | Recombinant Anti-Human ICAM1 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
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NEUT-923CQ | Mouse Anti-ICAM1 Recombinant Antibody (clone CBL236) | Neut, IF, FC, WB, IHC | Mouse IgG1 |
NEUT-925CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-925CQ) | FC, FuncS, IHC, Neut, WB | Mouse IgG1, κ |
NEUT-926CQ | Mouse Anti-ICAM1 Recombinant Antibody (VMC182) | FC, IF, IHC, ICC, Neut | Mouse IgG2b |
NEUT-927CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-927CQ) | FC, IF, IHC, Neut, WB, ELISA | Mouse IgG1 |
NEUT-930CQ | Rat Anti-Icam1 Recombinant Antibody (NEUT-930CQ) | FC, FuncS, IHC-Fr, Neut, IP | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
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NEUT-924CQ | Mouse Anti-ICAM1 Recombinant Antibody (clone HCD54) | FC, IF, Block | Mouse IgG1, κ |
NEUT-928CQ | Mouse Anti-ICAM1 Recombinant Antibody (VMC183) | Block, FC, IHC, IP | Mouse IgG1 |
NEUT-929CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-929CQ) | Block, WB, IP, ICC | Mouse IgG1 |
CAT | Product Name | Application | Type |
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MOR-1723 | Rabbit Anti-ICAM1 Recombinant Antibody (clone DS1723AB), Biotin | IHC-Fr, IP, WB, ELISA | Rabbit IgG |
MOR-1724 | Rabbit Anti-Icam1 Recombinant Antibody (clone DS1724AB) | ELISA | Rabbit IgG |
MOR-4598 | Rabbit Anti-ICAM1 Recombinant Antibody (clone TH111DS) | WB, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
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EPAF-1635LC | Mouse Anti-ICAM1 Recombinant Antibody (clone c78.4A) | FC | Mouse IgG |
CAT | Product Name | Application | Type |
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MRO-0805-CN | Mouse Anti-ICAM1 Recombinant Antibody (clone F11-A4) | WB, IF, IHC | Mouse IgG1a |
MRO-0806-CN | Mouse Anti-ICAM1 Recombinant Antibody (clone J0-F7) | WB, IF, IHC, FC | Mouse IgG2a |
MRO-0807-CN | Rabbit Anti-ICAM1 Recombinant Antibody (clone CBACN-298) | WB, IF, IHC | Rabbit IgG |
HPAB-662-FY | Human Anti-ICAM1 Recombinant Antibody (HPAB-662-FY) | Inhib, ELISA | Human IgG1 |
VS3-WK1485 | Mouse Anti-ICAM1 Recombinant Antibody (clone CT12) | FC, IF | Mouse IgG1 |
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VS-0724-YC1353 | AbPlus™ Anti-Icam1 Magnetic Beads (VS-0724-YC1353) | IP, Protein Purification |
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VS-0125-FY45 | Human Anti-ICAM1 (clone 1A6) scFv-Fc Chimera | ADCC | Human IgG1, scFv-Fc |
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VS-0225-XY121 | CytoStream™ Mouse Anti-ICAM1 Recombinant Antibody (clone HA58) | FC | Mouse IgG1, kappa |
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VS-0425-YC540 | Recombinant Anti-ICAM1 Vesicular Antibody, EV Displayed (VS-0425-YC540) | ELISA, FC, Neut, Cell-uptake |
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VS-0525-XY3367 | Anti-Mouse ICAM1 Immunohistochemistry Kit | IHC | |
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