Recombinant Anti-ITGAV Vesicular Antibody, EV Displayed (VS-0425-YC298)
CAT#: VS-0425-YC298
The Recombinant Anti-ITGAV Vesicular Antibody, EV Displayed (VS-0425-YC298) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGAV-expressed cells or tissues. The ITGAV is integrin alpha V, part of adhesion receptors regulating cell signaling, and is associated with cancer and angiogenesis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/if_selected.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGAV
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit alpha V
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Integrin, Receptor
- Cellular Localization
- Focal adhesion sites, Cytosol
- Introduction
- The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
- Alternative Names
- CD51, MSK8, VNRA, VTNR
- Gene ID
- 3685
- UniProt ID
- P06756
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Datasheet
MSDS
COA
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