Recombinant Mouse Anti-αVβ3 Ectodomain Antibody scFv Fragment (17E6) (CAT#: PABX-191-S (P))
Anti-αVβ3 Ectodomain antibody is a Mouse of scFv class that binds to an αVβ3 Ectodomain. This antibody is a primate-specific mouse mAb that inhibits V integrins, is in phase II trials for treating cancer.
Specific Inquiry
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Figure 2 Species-dependent inhibition of cell attachment by 17E6 and species-independent inhibition by cilengitide.
Representative cell adhesion inhibition assay comparing human melanoma cell line WM164 (circles), monkey cell line CV-1 (triangles), and rat cell line Rat-1 (boxes). Filled symbols show response to 17E6, and open symbols show response to the RGD-peptide cilengitide. Human and monkey cells are inhibited, and rat cells are not affected by 17E6. Each species is inhibited by cilengitide.
Mahalingam, B., Van Agthoven, J. F., Xiong, J. P., Alonso, J. L., Adair, B. D., Rui, X., ... & Goodman, S. L. (2014). Atomic basis for the species-specific inhibition of αV integrins by mAb 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex. Journal of Biological Chemistry, jbc-M113.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Hen Lysozyme
- Species Reactivity
- Human
- Clone
- 17E6
- Applications
- Inhib Assay-Dependent
Neut Assay-Dependent
FuncS Assay-Dependent
Block Assay-Dependent
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody 17E6 scFv fragment can be used in applications of Inhib, Neut, FuncS, Block. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.
Target
- Alternative Names
- ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51);
- Gene ID
- 3685
- UniProt ID
- P06756
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-076 | Anti-Human CD51 Recombinant Antibody (TAB-076) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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