Recombinant Rat Anti-Itgav Antibody (RMV-7)
CAT#: NEUT-1582CQ
This antibody is a rat monoclonal antibody that binds specifically to mouse CD51 (Integrin alpha V), and it can neutralize the bioactivity of mouse CD51 (Integrin alpha V).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/ihc_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/10_E3_1_blue_red_green.jpg
Subcellular Location
Figure 5 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/15_E3_1_blue_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_9_3.jpg
Normal Tissue
Figure 8 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_9_4.jpg
Normal Tissue
Figure 9 Placenta
Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_2_7.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (RT4, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138448-ITGAV
❮
❯
Specifications
- Host Species
- Rat
- Type
- IgG1, κ
- Specificity
- Recognizes Mouse CD51 (Integrin alpha V)
- Species Reactivity
- Mouse
- Clone
- RMV-7
- Applications
- Used for immunoassay techniques such as: Flow Cytometry; Functional Studies; Immunoprecipitation; Neutralization
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze-thaw cycles.
Target
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Neutralizes Mouse CD51
We used this Rat monoclonal antibody (RMV-7) to neutralize Integrin alpha V (CD51) in mouse cell cultures. It effectively inhibited the bioactivity, allowing us to study cell adhesion mechanisms. The antibody is potent and works well for functional studies.
Clean Immunoprecipitation
In addition to neutralization, we used this antibody for Immunoprecipitation (IP) of CD51 from mouse lysates. It pulled down the target protein efficiently, and the subsequent analysis confirmed the interaction with extracellular matrix proteins.
Q&As
-
What species and protein does this antibody target?
A: This antibody binds specifically to Mouse CD51, which is also known as Integrin alpha V (Itgav). It is a Rat monoclonal antibody designed to recognize the mouse protein and neutralize its bioactivity in functional assays.
-
What is the host organism for this antibody?
A: The host organism for this antibody is Rat. It is a recombinant Rat monoclonal antibody (Clone RMV-7) with an IgG1 kappa isotype. It is purified via affinity chromatography and supplied as an unconjugated liquid.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# NEUT-1582CQ, RRID: AB_3714455)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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