Recombinant Anti-L1CAM Vesicular Antibody, EV Displayed (VS-0425-YC318)
CAT#: VS-0425-YC318
The Recombinant Anti-L1CAM Vesicular Antibody, EV Displayed (VS-0425-YC318) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to L1CAM-expressed cells or tissues. The L1CAM is an axonal glycoprotein that is crucial for neuronal development, with mutations leading to neurological syndromes like CRASH.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/208_G1_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/207_G1_1_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/206_G1_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining:
High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:
High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, RH-30, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198910-L1CAM
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- L1CAM
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- L1 cell adhesion molecule
- Biological Process
- Cell adhesion, Differentiation, Neurogenesis
- Molecular Function
- Developmental protein
- Cellular Localization
- Nucleoplasm, Plasma membrane
- Introduction
- The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus).
- Alternative Names
- CAML1, CD171, HSAS, HSAS1, MASA, MIC5, NCAM-L1, S10, SPG1
- Gene ID
- 3897
- UniProt ID
- P32004
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0635CL | Human Anti-L1CAM Recombinant Antibody (TAB-0635CL) | WB, IF, IHC, PK, ELISA, FC | Human antibody |
| TAB-0635CL-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (TAB-0635CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0635CL-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (TAB-0635CL-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0636CL | Anti-Human L1CAM Recombinant Antibody (L1-9.3) | WB, IHC, ELISA, FC | |
| TAB-0636CL-S(P) | Anti-Human L1CAM Recombinant Antibody scFv Fragment (L1-9.3) | WB, FC | |
| TAB-0636CL-F(E) | Anti-Human L1CAM Recombinant Antibody Fab Fragment (L1-9.3) | WB, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1999 | Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (DS1999AB) | ELISA, WB | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0398-CN-F(E) | Mouse Anti-L1CAM Recombinant Antibody; Fab Fragment (HPAB-0398-CN-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
| FAMAB-0191-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone G6); Fab Fragment | ELISA, IF, WB | Human Fab |
| FAMAB-0192-YC-F(E) | Human Anti-L1CAM Recombinant Antibody (clone H2); Fab Fragment | ELISA, IF, WB | Human Fab |
| HPAB-0827-CN-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (HPAB-0827-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
| HPAB-0828-CN-F(E) | Human Anti-L1CAM Recombinant Antibody; Fab Fragment (HPAB-0828-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0191-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone G6); scFv Fragment | ELISA, IF, WB | Human scFv |
| FAMAB-0192-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone H2); scFv Fragment | ELISA, IF, WB | Human scFv |
| HPAB-0827-CN-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0827-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-0828-CN-S(P) | Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0828-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-J0160-YC-S(P) | Human Anti-L1CAM Recombinant Antibody (clone Ab4); scFv Fragment | ELISA, FC, WB, FuncS | Human scFv |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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