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  • Human Anti-L1CAM Recombinant Antibody (clone H2); Fab Fragment

Human Anti-L1CAM Recombinant Antibody (clone H2); Fab Fragment (CAT#: FAMAB-0192-YC-F(E))

Provided are antibodies against mouse L1 from a human synthetic phage display library. The antibodies recognized mouse, but not human L1, by enzyme-linked immunosorbent assay, Western blot, and immunofluorescence staining of cultured neurons. Epitope mapping showed reactivity with the fibronectin type III repeats 1–2 of mouse L1. The antibodies stimulated neurite outgrowth from cerebellar dorsal, root ganglion and motor neurons when offered in substrate-coated form in a dose-dependent manner with maximal effects at approximately 32 nM.


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Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/208_G1_2_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/207_G1_1_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/206_G1_1_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Neuropil
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_B_8_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

Peripheral nerve/ganglion
Staining:

High

Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_A_7_3.jpg
Figure 6 Kidney
Figure 6 Kidney
(Collecting ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Distal tubules
Staining:

High

Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10896/27469_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, RH-30, RPTEC TERT1)
Figure 7 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, RH-30, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198910-L1CAM
Figure 7 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, RH-30, RPTEC TERT1)
Figure 7 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, RH-30, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198910-L1CAM

Specifications

  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human Fab
  • Specificity
  • Mouse L1CAM
  • Species Reactivity
  • Mouse
  • Clone
  • H2
  • Applications
  • ELISA, IF, WB

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • L1; CD171; NCAM-L1; N-CAM-L1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1178z Mouse Anti-L1CAM Recombinant Antibody (clone 8A2) WB, FC, ICC, IF, IHC, IP Mouse IgG1
MOB-0910CT Recombinant Mouse anti-Human L1CAM Monoclonal antibody (6H4) FC
MRO-0911-CN Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (JM11-05) WB, IHC Rabbit IgG
FAMAB-1631CQ Mouse Anti-L1CAM Recombinant Antibody (clone L1-14.10) IP, WB, FC, IF, IHC Mouse IgG1
ZG-0304C Mouse Anti-L1CAM Recombinant Antibody (ZG-0304C) WB Mouse IgG

Human Antibody

CAT Product Name Application Type
TAB-0635CL Human Anti-L1CAM Recombinant Antibody (TAB-0635CL) WB, IF, IHC, PK, ELISA, FC Human antibody
TAB-0635CL-S(P) Human Anti-L1CAM Recombinant Antibody; scFv Fragment (TAB-0635CL-S(P)) ELISA, FC Human scFv
TAB-0635CL-F(E) Human Anti-L1CAM Recombinant Antibody; Fab Fragment (TAB-0635CL-F(E)) ELISA, FC Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-0636CL Anti-Human L1CAM Recombinant Antibody (L1-9.3) WB, IHC, ELISA, FC
TAB-0636CL-S(P) Anti-Human L1CAM Recombinant Antibody scFv Fragment (L1-9.3) WB, FC
TAB-0636CL-F(E) Anti-Human L1CAM Recombinant Antibody Fab Fragment (L1-9.3) WB, FC

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1999 Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (DS1999AB) ELISA, WB IgG
MOR-4297 Hi-Affi™ Recombinant Rabbit Anti-L1CAM Monoclonal Antibody (SI384DS) FC IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0398-CN-S(P) Mouse Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0398-CN-S(P)) WB, ELISA, FC, IHC Mouse scFv
FAMAB-0191-YC-S(P) Human Anti-L1CAM Recombinant Antibody (clone G6); scFv Fragment ELISA, IF, WB Human scFv
FAMAB-0192-YC-S(P) Human Anti-L1CAM Recombinant Antibody (clone H2); scFv Fragment ELISA, IF, WB Human scFv
HPAB-0827-CN-S(P) Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0827-CN-S(P)) WB, ELISA, IHC, FC Human scFv
HPAB-0828-CN-S(P) Human Anti-L1CAM Recombinant Antibody; scFv Fragment (HPAB-0828-CN-S(P)) WB, ELISA, IHC, FC Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0398-CN-F(E) Mouse Anti-L1CAM Recombinant Antibody; Fab Fragment (HPAB-0398-CN-F(E)) WB, ELISA, FC, IHC Mouse Fab
HPAB-J0160-YC-F(E) Human Anti-L1CAM Recombinant Antibody (clone Ab4); Fab Fragment ELISA, FC, WB, FuncS Human Fab
HPAB-0561-YJ-F(E) Mouse Anti-L1CAM Recombinant Antibody (clone A10-A3); Fab Fragment ELISA, FC, FuncS Mouse Fab
HPAB-0562-YJ-F(E) Human Anti-L1CAM Recombinant Antibody (clone cA10-A3); Fab Fragment ELISA, FC, FuncS Chimeric (mouse/human) Fab
HPAB-0563-YJ-F(E) Human Anti-L1CAM Recombinant Antibody (clone HzA10A3-2.1); Fab Fragment ELISA, FC, FuncS Humanized Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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