Recombinant Anti-LGR5 Vesicular Antibody, EV Displayed (VS-0425-YC634) (CAT#: VS-0425-YC634)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• LGR5

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Leucine rich repeat containing G protein-coupled receptor 5

• Molecular Function
• G-protein coupled receptor, Receptor, Transducer

• Cellular Localization
• Nucleoplasm, Vesicles, Primary cilium transition zone, Centrosome, Basal body

• Introduction
• The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development.

• Alternative Names
• FEX, GPR49, GPR67, HG38

• Gene ID
• 8549

• UniProt ID
• O75473

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