Recombinant Mouse Anti-PTPRC Antibody (VS3-FY294)
CAT#: VS3-FY294
This product is a recombinant mouse antibody that recognizes human PTPRC. The antibody detects endogenous CD45 proteins protein. The mAb was purified by affinity chromatography purified protein. It can detect a band of approximately 147 kDa.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Normal Tissue
Figure 2 Appendix
Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- The antibody detects endogenous CD45 proteins.
- Species Reactivity
- Human
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- 147 kDa
Product Property
- Purification
- Affinity Chromatography Purified
- Purity
- >95%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 50% Glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western blotting: 1/2000
Target
- Alternative Names
- B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
- Gene ID
- 5788
- UniProt ID
- P08575
- Sequence Similarities
- Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Heavily N- and O-glycosylated.
- Protein Refseq
- NP_002829.3; NP_563578.2
- Function
- Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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|---|---|---|---|
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| TAB-243LC-F(E) | Anti-Human PTPRC Recombinant Antibody Fab Fragment (VHQ/humV2 ) | ELISA, FC | Humanized antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245LC | Human Anti-PTPRC Recombinant Antibody (TAB-245LC) | ELISA, FC | Human IgG2, κ |
| TAB-246LC | Human Anti-PTPRC Recombinant Antibody (TAB-246LC) | ELISA, FC | Human IgG2, κ |
| TAB-247LC | Human Anti-PTPRC Recombinant Antibody (TAB-247LC) | ELISA, FC | Human IgG2, κ |
| TAB-248LC | Human Anti-PTPRC Recombinant Antibody (TAB-248LC) | ELISA, FC | Human IgG2, κ |
| TAB-249LC | Human Anti-PTPRC Recombinant Antibody (TAB-249LC) | ELISA, FC | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0051MZ | Recombinant Mouse Anti-Human CD45 Antibody (clone A290-11242) | FC, IHC | Mouse antibody |
| HPAB-0258-FY | Mouse Anti-PTPRC Recombinant Antibody (HPAB-0258-FY) | ELISA | Mouse IgG1 |
| HPAB-1058-FY | Human Anti-PTPRC Recombinant Antibody (HPAB-1058-FY) | ELISA, Neut | Human IgG |
| ZG-0253U | Mouse Anti-PTPRC Recombinant Antibody (clone 17H9D4) | ELISA, WB, IHC, IF, FC | Mouse IgG2b |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0466MZ | Chicken Anti-PTPRC Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1895CQ | Recombinant Mouse Anti-PTPRC Antibody (HI30) | WB, IP, IHC-Fr, FuncS, ICC, FC, IHC-P, BL | IgG1 |
| NEUT-1896CQ | Recombinant Mouse Anti-Ptprc Antibody (104-2) | FC, IP, BL, IHC-Fr, ICC, IF | IgG2a, κ |
| NEUT-1897CQ | Recombinant Rat Anti-Ptprc Antibody (MAB0822) | BL, FC, IP, WB | IgG2 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2933 | Hi-Affi™ Recombinant Rabbit Anti-PTPRC Monoclonal Antibody (DS2933AB) | IP, WB | IgG |
| MOR-0089-FY | Rabbit Anti-PTPRC Recombinant Antibody (clone AFY0060) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-S(P) | Rabbit Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0365-CN-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0366-CN-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0366-CN-S(P)) | ELISA, FC | Human scFv |
| FAMAB-0006-CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); scFv Fragment | FC | Mouse scFv |
| HPAB-0258-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0258-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-1058-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-1058-FY-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-023CN | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4) | FC, IF | Mouse IgG1, κ |
| NS-023CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); Fab Fragment | FC, IF | Mouse Fab |
| NS-023CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); scFv Fragment | FC, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0006-CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); Fab Fragment | FC | Mouse Fab |
| HPAB-0258-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0258-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-M0191-YC-F(E) | Human Anti-PTPRC Recombinant Antibody (clone M/YC-14); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0536-FY-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0536-FY-F(E)) | Inhib, FuncS | Human Fab |
| HPAB-0537-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0537-FY-F(E)) | FC, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY220 | AbPlus™ Anti-PTPRC Magnetic Beads (YTH54.12) | IP, Protein Purification | |
| VS-0724-YC1181 | AbPlus™ Anti-PTPRC Magnetic Beads (VS-0724-YC1181) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY98 | Mouse Anti-NHP PTPRC Recombinant Antibody (clone MEM55) | IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY185 | CytoStream™ Rat Anti-PTPRC Recombinant Antibody (clone 30-F11) | FC | Rat IgG2b, kappa |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY86 | Human Anti-PTPRC (clone VHE-N73D/humV1) scFv-Fc Chimera | IF, FC | Human IgG1, scFv-Fc |
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| VS-0425-YC529 | Recombinant Anti-PTPRC Vesicular Antibody, EV Displayed (VS-0425-YC529) | ELISA, FC, Neut, Cell-uptake |
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