Recombinant Anti-Tgfbr1 Vesicular Antibody, EV Displayed (VS-0425-YC39)
CAT#: VS-0425-YC39
The Recombinant Anti-Tgfbr1 Vesicular Antibody, EV Displayed (VS-0425-YC39) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to Tgfbr1-expressed cells or tissues. The Tgfbr1 is a receptor for TGF-beta, part of a signaling pathway affecting cellular responses like proliferation and apoptosis, with knockout models showing impaired angiogenesis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56473/985_F7_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2441/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31481/66574_B_9_5.jpg
Normal Tissue
Figure 4 Cerebellum
Cells in granular layer Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31481/66574_B_8_8.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31481/66574_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31481/66574_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106799-TGFBR1
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- Tgfbr1
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Transforming growth factor beta receptor 1
- Biological Process
- Apoptosis, Differentiation, Growth regulation
- Molecular Function
- Kinase, Receptor, Serine/threonine-protein kinase, Transferase
- Cellular Localization
- Plasma membrane, Primary cilium
- Introduction
- This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality.
- Alternative Names
- ALK5, Alk-5, ESK2, TGFR-1, TbetaR-I, TbetaRI
- Gene ID
- 21812
- UniProt ID
- Q3U485
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Related Signaling Pathways
JAK-STAT Signaling Pathway
TGF-β Signaling Pathway
Related Diseases
Pancreatic Cancer
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TGFBR1"
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| MOB-4032z | Mouse Anti-TGFBR1 Recombinant Antibody (clone 43H12) | WB, ELISA, IHC | Mouse IgG1 |
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| MOB-2021CT | Recombinant Mouse anti-Human TGFBR1 Monoclonal antibody (9B22) | IHC-P |
| CAT | Product Name | Application | Type |
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| ZG-0114C | Mouse Anti-TGFBR1 Recombinant Antibody (clone ABT-TGFR1) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
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| ZG-0115C | Mouse Anti-TGFBR1 Recombinant Antibody (clone ABT-TGFR2) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ919 | Mouse Anti-TGFBR1 Recombinant Antibody (VS3-CJ919) | IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
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| VS-0525-XY7216 | Anti-Mouse TGFBR1 Immunohistochemistry Kit | IHC |
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