Recombinant Mouse Anti-TYR Antibody (clone 8H8-6G5-6H3) (CAT#: VS3-FY1502)

• Immunogen
• Synthetic peptides derived from human tyrosinase.

• Host Species
• Mouse

• Type
• Mouse IgA

• Specificity
• Human TYR

• Species Reactivity
• Human

• Clone
• 8H8-6G5-6H3

• Applications
• Immunohistochemistry-Paraffin

• Conjugate
• Unconjugated

• Purification
• Affinity Chromatography

• Purity
• >95% as determined by SDS-PAGE

• Buffer
• PBS, pH 7.3, 50% glycerol, 0.5% BSA

• Preservative
• 0.02% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry-Paraffin: 1/100-1/500

• Alternative Names
• Tyrosinase; Oculocutaneous Albinism IA; Tumor Rejection Antigen AB; Monophenol Monooxygenase; EC 1.14.18.1; LB24-AB; SK29-AB

• Gene ID
• 7299

• UniProt ID
• P14679

• Sequence Similarities
• Belongs to the tyrosinase family.

• Cellular Localization
• Membrane

• Post Translation Modifications
• Glycosylated.

• Protein Refseq
• NP_000363.1

• Function
• This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity).
  Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity).
  In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).

Secondary Antibody

• 2RD-A1442-YJ
• Goat Anti-Mouse IgA Secondary antibody

• 2RD-A1563-YJ
• Rabbit Anti-Mouse IgA Secondary antibody (Clone RM220)

Reconstitution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS