Recombinant Mouse Anti-TYR Antibody (clone 8H8-6G5-6H3)
CAT#: VS3-FY1502
This product is a recombinant mouse antibody that recognizes TYR. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 8H8-6G5-6H3 is specific for human TYR. The antigen is synthetic peptides derived from human tyrosinase.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43241/1291_D5_4_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077498-TYR/subcellular
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IHC-P
Figure 1. Recombinant Mouse Anti-TYR Antibody (clone 8H8-6G5-6H3) in IHC-P.
Immunohistochemical analysis of paraffin-embedded malignant melanoma using tyrosinase antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
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Specifications
- Immunogen
- Synthetic peptides derived from human tyrosinase.
- Host Species
- Mouse
- Type
- Mouse IgA
- Specificity
- Human TYR
- Species Reactivity
- Human
- Clone
- 8H8-6G5-6H3
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- Tyrosinase; Oculocutaneous Albinism IA; Tumor Rejection Antigen AB; Monophenol Monooxygenase; EC 1.14.18.1; LB24-AB; SK29-AB
- Gene ID
- 7299
- UniProt ID
- P14679
- Sequence Similarities
- Belongs to the tyrosinase family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylated.
- Protein Refseq
- NP_000363.1
- Function
- This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity).
Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity).
In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "Tyr"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1019-F(E) | Recombinant Anti-Tyr Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| MHH-1019-F(E) | Recombinant Human Anti-Tyr Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1019-S(P) | Recombinant Anti-Tyr Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-1019-S(P) | Recombinant Human Anti-Tyr Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0343MZ | Recombinant Mouse Anti-Human TYR Antibody (clone U312) | IHC | Mouse antibody |
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| MRO-1544-CN | Rabbit Anti-TYR Recombinant Antibody (clone JA52-11) | WB, IF, IHC | Rabbit IgG |
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| VS13-YC1194 | Rabbit Anti-TYR Recombinant Antibody (VS13-YC1194) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3734 | Rabbit Anti-TYR Recombinant Antibody (clone DS3734AB) | IHC-P, WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ655 | Mouse Anti-TYR Recombinant Antibody (VS3-CJ655) | IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7664 | Anti-TYR Immunohistochemistry Kit | IHC | |
| VS-0525-XY7665 | Anti-Mouse TYR Immunohistochemistry Kit | IHC |
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