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APP

rAbs(440)
Scaffolds(2)
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APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in APP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Anti-Human Abeta Therapeutic Antibody (Bapineuzumab) (TAB-225)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Inquiry
Anti-Human Abeta Therapeutic Antibody (Crenezumab) (TAB-226)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
WB, IF, IP, Neut, FuncS, ELISA, FC
Inquiry
Anti-APP Therapeutic Antibody (Aducanumab) (TAB-717)
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Inquiry
Anti-Human Abeta Therapeutic Antibody (Solanezumab) (TAB-228)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Inquiry
Anti-Human Abeta Therapeutic Antibody (Ponezumab) (TAB-227)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, ELISA, IP, FC, FuncS, Neut, IF
Inquiry
Anti-Human Abeta Therapeutic Antibody (Gantenerumab) (TAB-229)
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Inquiry
Recombinant Mouse Anti-APP Antibody (12A11 ) (PABL-010)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IF, FuncS
Inquiry
Recombinant Mouse Anti-APP Antibody (3D6) (PABL-011)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Inquiry
Recombinant Human Anti-APP Antibody (9TL) (PABL-012)
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS
Inquiry
Recombinant Anti-Human APP VHH Single Domain Antibody (NABG-016)
Species Reactivity:
Human
Type:
Llama VHH
Application:
CA, IP, IF, FuncS
Inquiry
Afuco™ Anti-Human APP ADCC Theraputic Antibody (BAN2401), ADCC Enhanced (AFC-050CL)
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Inquiry
Recombinant Mouse Anti-APP Antibody Fab Fragment (12A11 ) (PFBL-010)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, IF, FuncS
Inquiry
Recombinant Mouse Anti-APP Antibody Fab Fragment (3D6) (PFBL-011)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Inquiry
Recombinant Human Anti-APP Antibody Fab Fragment (9TL) (PFBL-012)
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, FuncS
Inquiry
Recombinant Mouse Anti-APP Antibody Fab Fragment (C705) (PFBL-013)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Inquiry
Recombinant Anti-Human APP VHH Single Domain Antibody (G7) (PNBL-003)
Derivation:
Llama
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, FuncS
Inquiry
Recombinant Anti-Human APP VHH Single Domain Antibody (PS2-8) (PNBL-004)
Derivation:
Llama
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, FuncS
Inquiry
Recombinant Anti-APP VHH Single Domain Antibody (KW1) (PNBL-070)
Derivation:
Llama
Species Reactivity:
Human
Type:
Llama VHH
Application:
ELISA, Neut, WB, Inhibition
Inquiry
Recombinant Mouse Anti-APP Antibody (PFA1) (PABW-009)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Inquiry
Recombinant Mouse Anti-APP Antibody (PFA2) (PABC-010)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Inquiry
Recombinant Anti-Human APP Antibody (MOB-1185z)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Inquiry
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