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APP

rAbs(307)
Scaffolds(2)
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This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Anti-Human Abeta Therapeutic Antibody (Bapineuzumab) (TAB-225)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Inquiry
Anti-Human Abeta Therapeutic Antibody (Crenezumab) (TAB-226)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
WB, IF, IP, Neut, FuncS, ELISA, FC
Inquiry
Anti-APP Therapeutic Antibody (Aducanumab) (TAB-717)
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Inquiry
Anti-Human Abeta Therapeutic Antibody (Solanezumab) (TAB-228)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Inquiry
Anti-Human Abeta Therapeutic Antibody (Ponezumab) (TAB-227)
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, ELISA, IP, FC, FuncS, Neut, IF
Inquiry
Anti-Human Abeta Therapeutic Antibody (Gantenerumab) (TAB-229)
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Inquiry
Afuco™ Anti-Human APP ADCC Theraputic Antibody (BAN2401), ADCC Enhanced (AFC-050CL)
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Inquiry
Recombinant Mouse Anti-APP Antibody Fab Fragment (12A11 ) (PFBL-010)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, IF, FuncS
Inquiry
Recombinant Mouse Anti-APP Antibody Fab Fragment (3D6) (PFBL-011)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Inquiry
Recombinant Anti-Human APP Antibody (MOB-1185z)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Inquiry
Recombinant Anti-Human APP Antibody Fab Fragment (MOB-1185z-F(E))
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IF, FC, FuncS
Inquiry
Recombinant Anti-Human APP Antibody scFv Fragment (MOB-1185z-S(P))
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
Inquiry
Recombinant Anti-Human APP VHH Single Domain Antibody (NABG-016)
Species Reactivity:
Human
Type:
Llama VHH
Application:
CA, IP, IF, FuncS
Inquiry
Z-domain of protein A scaffold protein anti-Human amyloid beta (Aβ) peptides (SZA-L226)
Scaffold Name:
Z-domain of protein A
Target:
Human amyloid beta (Aβ) peptides
Species Reactivity:
Human
Derivation:
Phage display
Inquiry
Z-domain of protein A scaffold protein anti-Human amyloid beta (Aβ) peptides (SZA-L227)
Scaffold Name:
Z-domain of protein A
Target:
Human amyloid beta (Aβ) peptides
Species Reactivity:
Human
Derivation:
Phage display
Inquiry
Recombinant Mouse Anti-APP Antibody (WO2) (PABZ-211)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB
Inquiry
Recombinant Mouse Anti-APP Antibody (10D5) (PABL-401)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB
Inquiry
Recombinant Mouse Anti-APP Antibody (12B4) (PABL-402)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB
Inquiry
Recombinant Mouse Anti-APP Antibody (c706) (PABL-403)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Inquiry
Recombinant Human Anti-APP Antibody Fab Fragment (9TL) (PFBL-012)
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, FuncS
Inquiry
Recombinant Mouse Anti-APP Antibody Fab Fragment (C705) (PFBL-013)
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Inquiry
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