Products
Loading...

APP

More+
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
WB, IF, IP, Neut, FuncS, ELISA, FC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Scaffold Name:
Z-domain of protein A
Target:
Human amyloid beta (Aβ) peptides
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
Z-domain of protein A
Target:
Human amyloid beta (Aβ) peptides
Species Reactivity:
Human
Derivation:
Phage display
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IF, FC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, ELISA, IP, FC, FuncS, Neut, IF
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
BL
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, IF, FuncS
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-381-2994    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2018 Creative-Biolabs All Rights Reserved