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APP

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APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in APP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
WB, IF, IP, Neut, FuncS, ELISA, FC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, ELISA, IP, FC, FuncS, Neut, IF
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS
Species Reactivity:
Human
Type:
Llama VHH
Application:
CA, IP, IF, FuncS
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Derivation:
Llama
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, FuncS
Derivation:
Llama
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, FuncS
Derivation:
Llama
Species Reactivity:
Human
Type:
Llama VHH
Application:
ELISA, Neut, WB, Inhibition
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
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