Anti-Human Abeta Recombinant Antibody (TAB-229) (CAT#: TAB-229)
Recombinant monoclonal antibody to Abeta. It is a monoclonal antibody for the treatment of Alzheimer's disease. A phase I clinical trial has been conducted in 2006/07. It is currently being evaluated in a prodromal Alzheimer's Disease population in the Scarlet Road study, a global phase II study of approximately 360 subjects in 100 centers in 15 countries.
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ELISA
Figure 1 Anti-Human Abeta Antibody (TAB-229) in ELISA
ELISA analysis of TAB-229 was performed by coating with recombinant human Beta-amyloid 42 with His & GST Tag (10703-H20E2) (1 μg/mL). Then blocked with BSA and incubated with Anti-Human Abeta Antibody (TAB-229) at a starting concentration of 2.5 ng/mL. The HRP-conjugated goat anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
WB
Figure 2 Anti-Human Abeta Antibody (TAB-229) in WB
Western blot analysis was performed by loading 1 µg (lane 1, Non-Reduced) and 1 µg (lane 2, Reduced) recombinant human Beta-amyloid 42 with His & GST Tag (10703-H20E2) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least 1 hour. Membranes were probed with Anti-Human Abeta Antibody (TAB-229) at a concentration of 1 μg/mL overnight at 4°C on a rocking platform. Then probed with Goat anti-Human IgG HRP secondary antibody at a dilution of 1:8,000 for one hour. Chemiluminescent was detected.
DB
Figure 3 Anti-Human Abeta Antibody in DB
Dot Blot analysis of TAB-229 was performed by coating with Human Abeta Protein (His Tag).
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- FuncS, IF, Neut, ELISA, FC, IP, ICC, IHC, Inhib
- MW
- 146.3 kDa
- Related Disease
- Alzheimer's disease (AD)
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The APP antibody has been reported in applications of FuncS, IF, Neut, ELISA, FC, IP, ICC, IHC, Inhib.
Target
- Alternative Names
- Gantenerumab;89957-37-9;R1450;R04909832;RG1450;7.9H7;APP;amyloid beta (A4) precursor protein;AD1, Alzheimer disease;amyloid beta A4 protein;peptidase nexin II;preA4;protease nexin-II;peptidase nexin-II;beta-amyloid peptide;alzheimer disease amyloid protei
- Gene ID
- 351
- UniProt ID
- P05067
Related Resources
Please refer to Gantenerumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Gantenerumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-401 | Mouse Anti-APP Recombinant Antibody (clone 10D5) | IF, FuncS | Mouse IgG2a |
| PABL-402 | Mouse Anti-APP Recombinant Antibody (clone 12B4) | WB | Mouse IgG2a |
| PABL-403 | Mouse Anti-APP Recombinant Antibody (PABL-403) | ELISA | Mouse IgG1, κ |
| PABL-404 | Mouse Anti-APP Recombinant Antibody (clone WO2) | WB, ELISA, FuncS | Mouse IgG |
| MOB-0071MZ | Mouse Anti-APP Recombinant Antibody (clone CDI912) | WB, ICC, ELISA | Mouse IgG1 |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-229, RRID: AB_3111888)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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