This human amyloid beta (Aβ) peptides specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=17nM) for human amyloid beta (Aβ) peptides as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-227 | Anti-Human Abeta Recombinant Antibody (Ponezumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG2 - kappa |
TAB-253CQ-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-253CQ-S(P)) | ELISA | Humanized scFv |
TAB-0828CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0828CLV-F(E)) | ELISA | Humanized Fab |
TAB-0829CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0829CLV-F(E)) | ELISA | Humanized Fab |
TAB-0830CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0830CLV-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-009 | Mouse Anti-APP Recombinant Antibody (clone PFA1); Fab Fragment | ELISA | Mouse IgG2a |
PFBC-010 | Mouse Anti-APP Recombinant Antibody (clone PFA2); Fab Fragment | ELISA | Mouse IgG2a |
HPAB-0241-FY-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0241-FY-F(E)) | Inhib | Mouse Fab |
HPAB-0242-FY-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0242-FY-F(E)) | WB | Humanized Fab |
HPAB-0104-YJ-F(E) | Mouse Anti-APP Recombinant Antibody (clone 5E3); Fab Fragment | ELISA, WB | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL D7) | ELISA, IHC | Single domain antibody |
TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL C2) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0022CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL H3) | ELISA, In vivo, FuncS | Single domain antibody |
TAB-0023CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL H6) | ELISA, In vivo, FuncS | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-252CQ | Mouse Anti-APP Recombinant Antibody (TAB-252CQ) | ELISA | Mouse IgG1 |
TAB-252CQ-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-252CQ-F(E)) | ELISA | Mouse Fab |
TAB-255CQ-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-255CQ-F(E)) | ELISA | Mouse Fab |
TAB-0792CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0792CLV-F(E)) | ELISA | Mouse Fab |
TAB-0792CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0792CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
TAB-0802CLV | Human Anti-APP Recombinant Antibody (TAB-0802CLV) | ELISA | Chimeric (mouse/human) IgG1, κ |
TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0789CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0801CLV | Anti-Human APP Recombinant Antibody (3H3) | IHC, FuncS | Fully human antibody |
TAB-0815CLV | Human Anti-APP Recombinant Antibody (TAB-0815CLV) | ELISA | Human IgG |
TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
TAB-0783CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0783CLV-S(P)) | ELISA, FuncS | Human scFv |
TAB-0815CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABC-394 | Mouse Anti-APP Recombinant Antibody (clone c#6) | ELISA, WB, FuncS | Mouse IgG1 |
PABC-395 | Mouse Anti-APP Recombinant Antibody (clone c#24) | ELISA, WB, FuncS | Mouse IgG1 |
MRO-1647-CN | Rabbit Anti-APP Polyclonal Antibody (MRO-1647-CN) | WB, IF, IHC, FC | Rabbit IgG |
HPAB-0345-YJ | Human Anti-APP Recombinant Antibody (clone B6) | ELISA, Inhib, WB | Human IgG |
HPAB-0346-YJ | Human Anti-APP Recombinant Antibody (clone B7) | ELISA, Inhib, WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0104-YJ-S(P) | Mouse Anti-APP Recombinant Antibody (clone 5E3); scFv Fragment | ELISA, WB | Mouse scFv |
HPAB-0105-YJ-S(P) | Human Anti-APP Recombinant Antibody (clone hu5E3); scFv Fragment | ELISA, WB | Humanized scFv |
HPAB-0993-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 16D4); scFv Fragment | ELISA | Mouse scFv |
HPAB-0345-YJ-S(P) | Human Anti-APP Recombinant Antibody (clone B6); scFv Fragment | ELISA, Inhib, WB | Human scFv |
HPAB-0346-YJ-S(P) | Human Anti-APP Recombinant Antibody (clone B7); scFv Fragment | ELISA, Inhib, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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