Anti-Human Abeta Recombinant Antibody (Ponezumab) (CAT#: TAB-227)
Recombinant monoclonal antibody to Abeta. Ponezumab is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- WB, ELISA, IP, FC, FuncS, Neut, IF
- CAS
- 1178862-65-1
- Generic Name
- Ponezumab
- UNII
- 1TG15H1XE9
- MW
- 148.3 kDa
- Related Disease
- Alzheimer's disease (AD)
Product Property
- Purity
- >95.0% as determined by analysis by RP-HPLC.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The APP antibody has been reported in applications of IF, IHC, WB, Inhib.
Inhibition: Approximately 24 h prior to measurements of vasodilatory responses animals were randomly administered 10 mg/kg i.p. ponezumab or an irrelevant IgG isotype control
Target
- Alternative Names
- Ponezumab;1178862-65-1;PF-04360365;RN-1219;RN1219;9TL;Ab2;APP;amyloid beta (A4) precursor protein;AD1, Alzheimer disease;amyloid beta A4 protein;peptidase nexin II;preA4;protease nexin-II;peptidase nexin-II;beta-amyloid peptide;alzheimer disease amyloid p
- Gene ID
- 351
- UniProt ID
- P05067
Related Resources
Please refer to Ponezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ponezumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ponezumab"
Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Abeta. It is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.
See other products for "APP"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Fab Antibody Products
Mouse Antibody Products
Single Domain Antibody Products
Humanized Antibody Products
Chimeric Antibody Products
Human Antibody Products
Chicken IgY Antibody Products
Rabbit Monoclonal Antibody Products
Epitope-Specific Antibody Products
Neuroscience Antibody Products
ADCC Enhanced Antibody Products
IgM Antibody Products
ScFv Antibody Products
Antibody Magnetic Beads
Non-Human Primate (NHP) Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1185z | Mouse Anti-APP Recombinant Antibody (clone 25F3) | WB, FC, ICC, IF, IHC | Mouse IgG1 |
| PABL-010 | Mouse Anti-APP Recombinant Antibody (clone 12A11) | WB, IF, FuncS | Mouse IgG2a, κ |
| HPAB-0346-FY | Mouse Anti-APP Recombinant Antibody (clone IBL-102) | FC, FuncS | Mouse IgG |
| ZG-0306F | Mouse Anti-APP Recombinant Antibody (ZG-0306F) | WB, IHC, ELISA | Mouse IgG |
| VS3-WK2020 | Rabbit Anti-APP (pT743) Recombinant Antibody (clone R07-4D0) | WB, ICC, IF, IP | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TAB-227. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IF, FuncS
Application: ELISA, SPR, Inhib, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
