Recombinant monoclonal antibody to Abeta. It binds to the amyloid-β peptides that make up the protein plaques seen in the brains of people with the disease.
Figure 1 shows the mean change over the course of 18 months of treatment with solanezumab or placebo for cognitive and functional outcomes.
For the ADAS-Cog14, as well as the ADAS-Cog11, significant differences between treatment groups were first observed at week 40 and were sustained through endpoint (week 80). For MMSE, the difference between treatment groups reached significance at endpoint. For the ADCS-iADL, significant differences between treatment groups were observed at week 64 and sustained through endpoint. No differences were evident between treatment groups for change from baseline on the ADCS-ADL, the ADCS-bADL subscale or the CDR-SB. The placebo versus active treatment group differences in the ADAS-Cog14 and ADCS-iADL increased over 18 months.
Siemers, E. R., Sundell, K. L., Carlson, C., Case, M., Sethuraman, G., Liu-Seifert, H., ... & Demattos, R. (2016). Phase 3 solanezumab trials: secondary outcomes in mild Alzheimer's disease patients. Alzheimer's & Dementia, 12(2), 110-120.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Abeta. It binds to the amyloid-β peptides that make up the protein plaques seen in the brains of people with the disease.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-225 | Anti-Human Abeta Recombinant Antibody (Bapineuzumab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
TAB-0828CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0828CLV-S(P)) | ELISA | Mouse scFv |
TAB-0829CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0829CLV-S(P)) | ELISA | Mouse scFv |
TAB-0830CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0830CLV-S(P)) | ELISA | Mouse scFv |
TAB-0831CLV-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0831CLV-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-229 | Anti-Human Abeta Recombinant Antibody (Gantenerumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
TAB-0343CL-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0343CL-S(P)) | ELISA, FuncS, In vivo | Human scFv |
TAB-0344CL-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0344CL-S(P)) | ELISA, FuncS, In vivo | Human scFv |
TAB-0343CL-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0343CL-F(E)) | ELISA, FuncS, In vivo | Human Fab |
TAB-0815CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0815CLV-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-010 | Mouse Anti-APP Recombinant Antibody (clone 12A11) | WB, IF, FuncS | Mouse IgG2a, κ |
PABL-011 | Mouse Anti-APP Recombinant Antibody (clone 3D6) | WB, ELISA, FuncS | Mouse IgG1 |
PABL-012 | Human Anti-APP Recombinant Antibody (clone 9TL) | WB, FuncS | Human IgG2, κ |
PABL-013 | Mouse Anti-APP Recombinant Antibody (clone C705) | WB, ELISA, FuncS | Mouse IgG |
HPAB-0116CQ | Mouse Anti-APP Recombinant Antibody (HPAB-0116CQ) | ELISA, WB, IP, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PNBL-003 | Recombinant Anti-Human APP VHH Single Domain Antibody (G7) | WB, ELISA, FuncS | Llama VHH |
PNBL-004 | Recombinant Anti-Human APP VHH Single Domain Antibody (PS2-8) | WB, ELISA, FuncS | Llama VHH |
TAB-0019CL-VHH | Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH) | IHC, WB | Camelid VHH |
TAB-0020CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL D7) | ELISA, IHC | Single domain antibody |
TAB-0021CL-VHH | Anti-Human APP VHH Single Domain Antibody (MPL C2) | ELISA, In vivo, FuncS | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-009 | Mouse Anti-APP Recombinant Antibody (clone PFA1); Fab Fragment | ELISA | Mouse IgG2a |
PFBC-010 | Mouse Anti-APP Recombinant Antibody (clone PFA2); Fab Fragment | ELISA | Mouse IgG2a |
HPAB-0116CQ-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0116CQ-F(E)) | ELISA, WB, IP, FuncS | Mouse Fab |
HPAB-0117CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0117CQ-F(E)) | ELISA, WB, IP, FuncS | Human Fab |
HPAB-0118CQ-F(E) | Human Anti-APP Recombinant Antibody (clone Fv1E4); Fab Fragment | ELISA, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-254CQ | Human Anti-APP Recombinant Antibody (TAB-254CQ) | ELISA | Chimeric (mouse/human) IgG1 |
TAB-254CQ-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P)) | ELISA | Mouse scFv |
TAB-254CQ-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-0789CLV | Human Anti-APP Recombinant Antibody (TAB-0789CLV) | IP | Chimeric (mouse/human) IgG |
TAB-0789CLV-F(E) | Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0789CLV-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0777CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0777CLV-F(E)) | ELISA | Mouse Fab |
TAB-0778CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0778CLV-F(E)) | ELISA | Mouse Fab |
TAB-0780CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0780CLV-F(E)) | ELISA | Mouse Fab |
TAB-0781CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0781CLV-F(E)) | ELISA | Mouse Fab |
TAB-0792CLV-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0792CLV-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0685MZ | Chicken Anti-APP Polyclonal IgY | IHC | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-014 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204) | WB, ELISA, FuncS | Rabbit IgG |
PABX-014-F (E) | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment | WB, ELISA, FuncS | Rabbit Fab |
MOR-0220 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB) | ELISA, WB | Rabbit IgG |
MOR-4539 | Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS) | IHC-P, ELISA | Rabbit IgG |
MOR-0082-FY | Rabbit Anti-APP Recombinant Antibody (clone AFY0053) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0566CQ | Mouse Anti-APP Recombinant Antibody (clone 6E10) | ELISA | Mouse IgG |
EPAF-0567CQ | Mouse Anti-APP Recombinant Antibody (clone 4G8) | ELISA, IHC | Mouse IgG2b |
EPAF-0568CQ | Human Anti-APP Recombinant Antibody (clone HyL5) | ELISA, Inhib | Human IgM |
EPAF-0569CQ | Mouse Anti-APP Recombinant Antibody (clone AB1-42) | IHC | Mouse IgG |
EPAF-0570CQ | Human Anti-APP Recombinant Antibody (clone L11.3) | IHC, ELISA, Inhib | Human IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-001CN | Human Anti-APP Recombinant Antibody (clone AS) | WB | Human IgG |
NS-007CN | Mouse Anti-APP Recombinant Antibody (NS-007CN) | ELISA, FuncS | Mouse IgG1 |
NS-001CN-F(E) | Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment | WB | Human Fab |
NS-007CN-F(E) | Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E)) | ELISA | Mouse Fab |
NS-001CN-S(P) | Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment | WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0176-FY-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0176-FY-S(P)) | AG | Mouse scFv |
HPAB-0120CQ-S(P) | Human Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0120CQ-S(P)) | ELISA, IHC, FuncS | Human scFv |
HPAB-0346-FY-S(P) | Mouse Anti-APP Recombinant Antibody (clone IBL-102); scFv Fragment | Cyt, WB, ELISA | Mouse scFv |
HPAB-S0005-YC-S(P) | Human Anti-APP Recombinant Antibody (clone ch3D6); scFv Fragment | ELISA, FuncS | Human scFv |
HPAB-1828-FY-F(E) | Mouse Anti-APP Recombinant Antibody (clone 2324); scFv Fragment | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-225 | Afuco™ Anti-APP ADCC Recombinant Antibody (Bapineuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-228 | Afuco™ Anti-APP ADCC Recombinant Antibody (Solanezumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-229 | Afuco™ Anti-APP ADCC Recombinant Antibody (Gantenerumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-227 | Afuco™ Anti-APP ADCC Recombinant Antibody (Ponezumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-226 | Afuco™ Anti-APP ADCC Recombinant Antibody (Crenezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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