Mouse Anti-APP Recombinant Antibody (clone 3D6)

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Q&As

1. Is this anti-APP recombinant antibody clone 3D6 suitable for Western blotting?

   A: Yes, the anti-APP recombinant antibody clone 3D6 (PABL-011) is suitable for Western blotting applications. It provides specific binding to APP, making it a reliable choice for such assays.

2. What are the recommended storage conditions for the anti-APP recombinant antibody clone 3D6?

   A: The recommended storage condition for the anti-APP recombinant antibody clone 3D6 (PABL-011) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To maintain stability, avoid repeated freeze-thaw cycles.

3. Can the anti-APP recombinant antibody clone 3D6 be used in immunoprecipitation assays?

   A: Yes, the anti-APP recombinant antibody clone 3D6 (PABL-011) can be used in immunoprecipitation assays. It is designed to effectively bind to APP, enabling the successful precipitation of the target protein from complex mixtures.

4. Is this anti-APP recombinant antibody clone 3D6 effective in ELISA applications?

   A: Yes, the anti-APP recombinant antibody clone 3D6 (PABL-011) is effective in ELISA applications. It has been validated for use in such assays and provides reliable detection of APP.

5. What is the optimal dilution for using the anti-APP recombinant antibody clone 3D6 in immunofluorescence?

   A: The optimal dilution for using the anti-APP recombinant antibody clone 3D6 (PABL-011) in immunofluorescence is typically 1:100 to 1:500. It is advisable to perform a dilution series to determine the best working concentration for specific experimental conditions.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Maniv, Inbal, et al. "Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model." Nature Communications 14.1 (2023): 5922. https://doi.org/10.1038/s41467-023-41545-7
   The study investigates the role of altered ubiquitin signaling in inducing Alzheimer's disease (AD)-like hallmarks using a three-dimensional human neural cell culture model. It highlights that the accumulation of the UBB+1 protein is an early event in Alzheimer's disease. The research demonstrates that UBB+1 expression induces AD pathology in human neurons by interacting with UCHL1 and altering APP protein levels. Notably, silencing UBB+1 expression rescues AD pathology in human familial AD (FAD) neurons.
   Creative Biolabs significantly contributed to this study by providing the 3D6 anti-amyloid-β antibody (Cat. no. PABL-011), which was used in immunofluorescence staining experiments. The use of this antibody was crucial for detecting amyloid-β aggregates, a key pathological feature of Alzheimer's disease, thus enabling the researchers to better understand and visualize the AD-like pathology in their 3D neural cell culture model.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# PABL-011, RRID: AB_3111619)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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