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AR

Anti-AR Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


At Creative Biolabs, cutting-edge platforms enable us to provide our global customers with comprehensive, high-quality AR-targeted recombinant antibody products. Our commitment is to promote research and discovery by providing unparalleled technical support and exceptional value, ensuring that our customers achieve their scientific goals in a timely and efficient manner.

AR: A Prominent Target in Cancer Therapy

The androgen receptor (AR) is a key nuclear transcription factor belonging to the steroid hormone nuclear receptor family. It is activated by androgens like testosterone and dihydrotestosterone and is found in various tissues. AR plays crucial roles in the reproductive, musculoskeletal, cardiovascular, immune, neural, and hematopoietic systems. AR signaling is also implicated in the development of tumors in organs such as the prostate, bladder, liver, kidney, and lung, with a particularly strong association with prostate cancer. Consequently, targeting AR holds significant promise for treating prostate cancer and other malignancies.

Alternative Names

Androgen receptor; NR3C4; nuclear receptor subfamily 3 group C member 4; AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor; Dihydrotestosterone receptor; Spinal And Bulbar Muscular Atrophy; Testicular Feminization; Kennedy Disease.

Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class

Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Hepatocytes, Granulosa cells, Breast glandular cells, Peritubular cells, Leydig cells, Skeletal myocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, BJ hTERT+, HAP1, LHCN-M2, RH-30, T-47d)

Interaction

Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (PubMed:19022849). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318 (By similarity). Interacts with BUD31 (PubMed:25091737). Interacts with ARID4A (PubMed:23487765). Interacts with ARID4B (By similarity). Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (PubMed:20812024). Interacts with NCOR1 (PubMed:20812024). Interacts with NCOR2 (PubMed:20812024). Interacts with CRY2 in a ligand-dependent manner (By similarity).

Molecular function

Activator, DNA-binding, Receptor

More Types Infomation

Anti-AR Recombinant Antibody Products

Based on our advanced platforms, our seasoned research team develops and provides various innovative and high-quality anti-AR recombinant antibody products. Robust quality control and top-notch technical support work together to empower our anti-AR recombinant antibody products to be applied to customers’ meaningful projects with exceptional value.

Cat. No. Product Name Target Species Host Species Applications
MRO-0092-CN Rabbit Anti-AR Recombinant Antibody (clone CBACN-027) Human Rabbit IgG WB, IF, IHC, FC
MOB-1873z Mouse Anti-AR Recombinant Antibody (clone 15B4) Human Mouse IgG1 WB, ELISA, FC, ICC, IF, IHC
MOR-0226 Hi-Affi™ Rabbit Anti-AR Recombinant Antibody (clone DS226AB) Human Rabbit IgG ICC, IHC-P, IP, WB
VS-0923-FY12 Recombinant Mouse Anti-AR Antibody Human Mouse IgG2a ELISA, WB
ZG-0586F Mouse Anti-AR Recombinant Antibody (clone F39.4.1) Human Mouse IgG1 Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Creative Quality Control

Our commitment to the biopharmaceutical community shines through in our unwavering dedication to supporting research and development. We ensure superior product quality and unmatched customer support. By adhering to a meticulous quality control system, we guarantee complete customer satisfaction. Our products are engineered to surpass industry standards, facilitating the efficient development of medications and delivering exceptional value to our customers.

Fig.1 WB analysis of anti-AR recombinant antibody (ZG-0548J). (Creative Biolabs Original)Fig.1 Anti-AR Recombinant Antibody in WB.
(Cat# ZG-0548J, Creative Biolabs).

Fig.2 IHC analysis of anti-AR recombinant antibody (ZG-0548J). (Creative Biolabs Original)Fig.2 Anti-AR Recombinant Antibody in IHC.
(Cat# ZG-0548J, Creative Biolabs).

Fig.3 IHC analysis of anti-AR recombinant antibody (ZG-0548J). (Creative Biolabs Original)Fig.3 Anti-AR Recombinant Antibody in IHC.
(Cat# ZG-0548J, Creative Biolabs).

Fig.4 IHC analysis of anti-AR recombinant antibody (ZG-0549J). (Creative Biolabs Original)Fig.4 Anti-AR Recombinant Antibody in IHC.
(Cat# ZG-0549J, Creative Biolabs).

Fig.5 IHC analysis of anti-AR recombinant antibody (ZG-0031J). (Creative Biolabs Original)Fig.5 Anti-AR Recombinant Antibody in IHC.
(Cat# ZG-0031J, Creative Biolabs).

Fig.6 WB analysis of anti-AR recombinant antibody (ZG-0307F). (Creative Biolabs Original)Fig.6 Anti-AR Recombinant Antibody in WB.
(Cat# ZG-0307F, Creative Biolabs).

Customer Reviews

Excellent
Ma***n
Recombinant Mouse Anti-AR Antibody (VS-0923-FY11) (CAT#: VS-0923-FY11)
I recently purchased the Recombinant Mouse Anti-AR Antibody for my ongoing research, and I must say, I am extremely satisfied with its performance. This antibody demonstrates exceptional specificity and affinity. It has greatly enhanced the accuracy of my experiments by binding to the AR with exceptional precision. The consistency from one lot to another is impressive, guaranteeing consistent results with each use. Additionally, the prompt delivery and dependable customer support contribute to the overall satisfaction when using these products. Suggested highly!
3/Nov/2023
Excellent
Be***d
Mouse Anti-AR Recombinant Antibody (VS4-WK35) (CAT#: VS4-WK35)
I've been using the Recombinant Mouse Anti-AR Antibody for several weeks now, mainly for immunocytochemistry on human cultured cells, specifically the prostate cancer cell line (LNCaP). The results have been exceptional. This antibody consistently delivers exceptional specificity and robust signal intensity, enabling effortless differentiation of AR expression patterns.
14/Feb/2024
Excellent
Ro***y
Rabbit Anti-AR Recombinant Antibody (clone CBACN-027) (CAT#: MRO-0092-CN)
Recently I bought the Anti-AR Antibody for use in Western Blot tests on Human Cultured Cells—prostate cancer cell line PC3. The antibody was very good, showing the presence of androgen receptor protein in the cell lysates by obvious, identifiable bands. The constant and repeatable nature of the outcomes simplified data interpretation. For researchers working with prostate cancer cell lines and doing Western blot analysis aiming at AR, I suggest this product.
26/Mar2024

Anti-AR Recombinant Antibody Production

Our innovative serum-free mammalian cell expression system provides complete services from gene synthesis to scalable, premium anti-AR recombinant antibody generation. Having more than five years of process optimization experience, we provide fast and reasonably priced options for quickly varying antibody supply in a short turnaround.

Featured Anti-AR Recombinant Antibody Production Platforms Fig.7 Anti-AR recombinant antibody production: Milligram-scale. (Creative Biolabs Original)
Fig.7 Milligram-scale anti-AR recombinant antibody production.

Fig.8 Anti-AR recombinant antibody production: Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-AR recombinant antibody production.

Anti-AR Recombinant Antibody Modalities

Creative Biolabs is committed to providing researchers with a wide range of innovative recombinant antibodies to aid in therapeutics development. We offer a wide range of anti-AR recombinant antibodies in different formats, including full-length, Fab, scFv, and more. With our deep knowledge and vast experience in antibody engineering, we are fully equipped to offer tailored solutions that cater to your unique research requirements.

Fig.9 The production and modalities of full-length anti-AR recombinant antibody. (Creative Biolabs Original)Fig.9 Full-Length Anti-AR Recombinant Antibody Production and Modalities

AR-Targeted Drug Information

Drug Information Targeting AR (Under Development)

Table 1. AR-targeted drug information (under development).

Company Highest Phase Classification Condition
ANI Pharmaceuticals
BioSante (ANI Pharmaceuticals)
Halozyme (Originator)
Teva
Registered - 2012 Androgens
Steroids
Cognitive disorders
Hormone replacement therapy
Hypogonadism
Sexual dysfunction, female
Barrier Therapeutics (Stiefel)
Stiefel (Originator)
Phase III Cancer Hormone Therapy
Corticosteroids
Fixed-Dose Combinations
Imidazoles, Antifungal Agents
Steroids
Seborrheic dermatitis
Lipocine (Originator)
Verity Pharmaceuticals
Phase II Prodrugs Hypogonadism
Lilly (Originator) Phase II Fixed-Dose Combinations Erectile dysfunction
Acerus Pharmaceuticals
Trimel Pharmaceuticals (Acerus Pharmaceuticals)
Phase II Androgens
Steroids
Anorgasmia, female
Merck & Co (Originator) Phase II Androgens
Fixed-Dose Combinations
Progestogens
Steroids
Contraception, male

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Drug Information Targeting AR (Launched)

Table 2. AR-targeted drug information (launched).

Company Highest Phase Drug Type Condition
Blue Water Vaccines
Veru (Originator)
Launched - 2022 Cancer Hormone Therapy
Fixed-Dose Combinations
Steroids
Prostatic hyperplasia, benign
Ferring (Originator) Launched - 2018 Androgens
Steroids
Hormone replacement therapy
Hypogonadism
Cadila Healthcare (d/b/a Zydus Cadila) (Zydus)
Merck & Co. (Merck & Co)
Merck Sharp & Dohme (MSD) (Originator)
Launched Androgens
Fixed-Dose Combinations
Steroids
Hormone replacement therapy

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Please contact us during your leisure time for more information on our anti-AR recombinant antibody products. Our team is excited about the prospect of working with you to advance your research and identify potential opportunities for mutual benefit.

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