CD markers, Plasma proteins, Transporters
Membrane
Cell type enhanced (Adipocytes, Theca cells, Hepatic stellate cells)
Low immune cell specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Isoform 1 and isoform 2 form homodimers and also heterodimers with each other. Dimerization is essential for its antiviral activity (PubMed:26378163, PubMed:10329429, PubMed:19737401, PubMed:19879838, PubMed:23028328, PubMed:20399176, PubMed:20880831, PubMed:20940320, PubMed:31199522). Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts with MMP14 (via C-terminal cytoplasmic tail) (PubMed:22065321). Interacts with LILRA4/ILT7 (PubMed:19564354). (Microbial infection) Interacts with ebola GP protein. (Microbial infection) Interacts (via transmembrane domain) with HIV-1 VPU (via transmembrane domain). (Microbial infection) Interacts with HIV-2 ENV. (Microbial infection) Interacts with SARS-CoV ORF7a protein.
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For Research Use Only. Not For Clinical Use.