Anti-CANX Recombinant Antibody Products

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Anti-CANX Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, the cell biology specialist, has highly specific anti-CANX recombinant antibodies for your research. Calnexin (CANX) is an ER chaperone and a key component of the endoplasmic reticulum (ER) quality control system. It is vital for the folding of newly synthesized glycoproteins. Creative Biolabs' premium antibodies are crucial reagents to study protein folding, ER stress and the unfolded protein response (UPR) within the cell.

CANX: A Guardian of Glycoprotein Folding in the ER

Calnexin (CANX) is a Type I integral membrane protein of the endoplasmic reticulum (ER) and a member of the molecular chaperones. Calnexin is an important regulator of the N-linked glycoprotein quality control process in the endoplasmic reticulum. It is responsible for recognizing, binding, and retaining monoglucosylated glycans present on newly synthesized polypeptide chains and halting the folding process to prevent aggregation. This cycle is collectively called the "calnexin/calreticulin cycle", where calnexin acts as a central hub for protein quality control alongside its soluble homolog calreticulin and other ER-resident enzymes.

Alternative Names

CNX; P90; IP90

Background

The protein encoded by this gene is a member of the calnexin family of molecular chaperones. The protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that transiently associates with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also serve a central role in the quality control of protein folding by sequestering misfolded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.

Anti-CANX rAb Products

Creative Biolabs' recombinant antibodies are produced for high specificity and performance. They are rigorously validated to reliably detect the calnexin protein, a definitive marker for the endoplasmic reticulum. Optimized for use in a range of applications, such as immunofluorescence for subcellular localization or co-immunoprecipitation to capture the chaperone-substrate complex, our recombinant antibodies (rAbs) are a staple for any cell biology laboratory.

Table 1. Featured anti-CANX recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs' mission is delivering accurate, reproducible science. For that reason, the manufacturing of our anti-CANX recombinant antibodies is underpinned by a strict quality control system. We test each lot for purity and specificity as well as consistent performance in validated applications so you can be confident you are receiving a reagent that will support your critical experiments.

Customer Reviews

Excellent

Z**ra
Mouse Anti-CANX Recombinant Antibody (ZG-0358F)

The anti-Calnexin antibody from Creative Biolabs is our ER marker of choice. The immunofluorescence staining works like magic. It's always perfect, giving us a beautiful reticular pattern with no off-target signal.

13/Oct/2024

rAb Production

Creative Biolabs takes a scientific approach to antibody production to support the specialized field of cell biology. Our anti-CANX recombinant antibodies are raised against the cytosolic tail of the protein for high-level detection in a variety of applications.

Featured Anti-CANX Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CANX recombinant antibody production.

Fig.4 Gram-scale anti-CANX recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering your scientific discovery with flexible antibody modalities. Our anti-CANX recombinant antibodies are available in a variety of formats and conjugations, customizable to meet the demands of your experiments. For applications like Western blotting, cellular imaging, or advanced research techniques we have the right reagent.

Fig.5 Full-length anti-CANX recombinant antibody production and modalities.

Take aim at protein quality control mechanisms with Creative Biolabs' anti-CANX recombinant antibodies. Experience the validation and lot-to-lot consistency you need to study this vital ER chaperone. Place your trust in our experience to provide a sound scientific basis for your research. Contact our scientific team today.