Recombinant Rabbit Anti-CANX Antibody (clone R07-2B1) (CAT#: VS3-FY186)
This product is a recombinant rabbit antibody that recognizes human CANX protein. It can detect a band of approximately 68 kDa (observedd molecular weight: 90 kDa).
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WB
Figure 1. Recombinant Rabbit Anti-CANX Antibody (clone R07-2B1) in WB.
Western blot analysis of Calnexin in K562 lysates using Calnexin Antibody.
Specifications
- Immunogen
- A synthetic peptide of human Calnexin
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CANX
- Species Reactivity
- Human
- Clone
- R07-2B1
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 68 kDa; Observed MW: 90 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Calnexin; Major Histocompatibility Complex Class I Antigen-Binding Protein P88; IP90; P90; CNX
- Gene ID
- 821
- UniProt ID
- P27824
- Sequence Similarities
- Belongs to the calreticulin family.
- Cellular Localization
- Endoplasmic reticulum, Membrane
- Post Translation Modifications
- Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
- Protein Refseq
- NP_001019820.1; NP_001737.1
- Function
- Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3830z | Mouse Anti-CANX Recombinant Antibody (clone 42H7) | WB, FC, ICC, IF, IHC | Mouse IgG2b, κ |
| MRO-1711-CN | Rabbit Anti-CANX Polyclonal Antibody (MRO-1711-CN) | WB, IHC, FC | Rabbit IgG |
| ZG-0358F | Mouse Anti-CANX Recombinant Antibody (ZG-0358F) | WB, IF, ELISA | Mouse IgG |
| VS3-QX149 | Mouse Anti-CANX Recombinant Antibody (clone 3H4A7) | WB, IHC, ICC, FC, ELISA | Mouse IgG2b |
| VS4-WK57 | Mouse Anti-CANX Recombinant Antibody (clone 4G3H3) | ELISA, WB, FC | Mouse IgG2a |
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