Recombinant Rabbit Anti-CANX Antibody (clone R07-2B1) (CAT#: VS3-FY186)
This product is a recombinant rabbit antibody that recognizes human CANX protein. It can detect a band of approximately 68 kDa (observedd molecular weight: 90 kDa).
Specific Inquiry
WB
Figure 1. Recombinant Rabbit Anti-CANX Antibody (clone R07-2B1) in WB.
Western blot analysis of Calnexin in K562 lysates using Calnexin Antibody.
Specifications
- Immunogen
- A synthetic peptide of human Calnexin
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CANX
- Species Reactivity
- Human
- Clone
- R07-2B1
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 68 kDa; Observed MW: 90 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Calnexin; Major Histocompatibility Complex Class I Antigen-Binding Protein P88; IP90; P90; CNX
- Gene ID
- 821
- UniProt ID
- P27824
- Sequence Similarities
- Belongs to the calreticulin family.
- Cellular Localization
- Endoplasmic reticulum, Membrane
- Post Translation Modifications
- Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
- Protein Refseq
- NP_001019820.1; NP_001737.1
- Function
- Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3830z | Mouse Anti-CANX Recombinant Antibody (clone 42H7) | WB, FC, ICC, IF, IHC | Mouse IgG2b, κ |
| MOB-0551MZ | Mouse Anti-CANX Recombinant Antibody (clone 7G23CF20) | FC, ICC, IP, ELISA | Mouse IgG2b |
| MRO-0214-CN | Rabbit Anti-CANX Recombinant Antibody (clone CBACN-079) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1711-CN | Rabbit Anti-CANX Polyclonal Antibody (MRO-1711-CN) | WB, IHC, FC | Rabbit IgG |
| VS3-CJ841 | Rabbit Anti-CANX Recombinant Antibody (VS3-CJ841) | WB, ICC, IF, IHC, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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