Rabbit Anti-CANX Recombinant Antibody (VS3-CJ841)
CAT#: VS3-CJ841
This product is a rabbit antibody that recognizes human, and rat CANX.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9433/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Cells in basal layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Cells in granular layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Endothelial cells Staining: High Intensity: Strong Fibrohistiocytic cells Staining: High Intensity: Strong Langerhans cells Staining: High Intensity: Strong Quantity: 75%-25% Lymphocytes Staining: High Intensity: Strong Melanocytes Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_B_8_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4738/11907_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (hTERT-HME1, SK-MEL-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000127022-CANX
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Rat CANX
- Species Reactivity
- Human, Rat
- Applications
- WB, ICC, IF, IHC, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- CNX; P90; IP90
- Gene ID
- 821
- UniProt ID
- P27824
- Sequence Similarities
- Belongs to the calreticulin family.
- Cellular Localization
- Endoplasmic reticulum, Membrane
- Post Translation Modifications
- Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
- Protein Refseq
- NP_001019820.1; NP_001737.1
- Function
- Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CANX"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3830z | Mouse Anti-CANX Recombinant Antibody (clone 42H7) | WB, FC, ICC, IF, IHC | Mouse IgG2b, κ |
| MOB-0551MZ | Mouse Anti-CANX Recombinant Antibody (clone 7G23CF20) | FC, ICC, IP, ELISA | Mouse IgG2b |
| MRO-1711-CN | Rabbit Anti-CANX Polyclonal Antibody (MRO-1711-CN) | WB, IHC, FC | Rabbit IgG |
| ZG-0358F | Mouse Anti-CANX Recombinant Antibody (ZG-0358F) | WB, IF, ELISA | Mouse IgG |
| VS3-FY186 | Recombinant Rabbit Anti-CANX Antibody (clone R07-2B1) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0456 | Hi-Affi™ Rabbit Anti-CANX Recombinant Antibody (clone DS456AB) | IHC-P, IP, WB | Rabbit IgG |
| MOR-0079-FY | Rabbit Anti-CANX Recombinant Antibody (clone AFY0050) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-013CN | Mouse Anti-CANX Recombinant Antibody (clone CGMCCNo.3240) | ELISA, WB, IHC, IP, IF | Mouse IgG2b |
| NS-013CN-F(E) | Mouse Anti-CANX Recombinant Antibody (clone CGMCCNo.3240); Fab Fragment | ELISA, WB, IHC, IP, IF | Mouse Fab |
| NS-013CN-S(P) | Mouse Anti-CANX Recombinant Antibody (clone CGMCCNo.3240); scFv Fragment | ELISA, WB, IHC, IP, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY40 | AbPlus™ Anti-CANX Magnetic Beads (CGMCCNo.3240) | IP, Protein Purification | |
| VS-0724-YC826 | AbPlus™ Anti-CANX Magnetic Beads (VS-0724-YC826) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY304 | Anti-CANX Immunohistochemistry Kit | IHC | |
| VS-0525-XY968 | Anti-Mouse CANX Immunohistochemistry Kit | IHC | |
| VS-0525-XY967 | Anti-Human CANX Immunohistochemistry Kit | IHC | |
| VS-0525-XY969 | Anti-Canine CANX Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC117 | CytoStream™ Rabbit Anti-CANX Recombinant Antibody (VS13-YC117) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC443 | Recombinant Anti-CANX Vesicular Antibody, EV Displayed (VS-0425-YC443) | ELISA, FC, Cell-uptake |
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