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    CD200R1

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Hofbauer cells, Langerhans cells, granulocytes, Basal squamous epithelial cells, Hepatic stellate cells, T-cells)

    Immune cell specificity

    Immune cell enriched (basophil)

    Cell line specificity

    Cell line enriched (HEL)

    Interaction

    CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein. (Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.

    Molecular function

    Receptor

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