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CD22

Anti-CD22 Products

Rat Anti-CD22 Recombinant Antibody (clone 2D6) (NEUT-315CQ)
- Species Reactivity: Mouse
- Type: Rat IgG1, κ
- Application: Block
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Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-176) (AFC-TAB-176)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: IF, IP, Neut, FuncS, ELISA, FC
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Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-198) (AFC-TAB-198)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, FC, IP, FuncS, IF, Neut
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Recombinant Anti-Human CD22 Antibody (Fab glycosylation) (Gly-001LC)
- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
- Glycosylation site: FR1 of VK
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Recombinant Anti-Human CD22 Antibody (Fc glycosylation) (Gly-111LC)
- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
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For Research Use Only. Not For Clinical Use.

Background

CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.